Formulation and Evaluation of Citronella Oil (Cymbopogon nardus (L.) Rendle) Cream for Acne Treatment

Q4 Pharmacology, Toxicology and Pharmaceutics

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI:10.25258/ijddt.13.1.67

T. L. Nareswari, Fidela O Vrince, Erga Syafi Tri

{"title":"Formulation and Evaluation of Citronella Oil (Cymbopogon nardus (L.) Rendle) Cream for Acne Treatment","authors":"T. L. Nareswari, Fidela O Vrince, Erga Syafi Tri","doi":"10.25258/ijddt.13.1.67","DOIUrl":null,"url":null,"abstract":"Acne is a prevalent skin disorder that aff ects 80–85% of teenagers globally. Citronella oil is one of the natural compounds that has been known to potentially treat acne, but its application is limited due to its greasiness and uncomfortable sensation on skin. This study aimed to optimize the concentration of cetyl alcohol as a viscosity enhancer that can produce a physically stable cream preparation and to evaluate the antibacterial activity of the optimized formula against Propionibacterium acnes. Following the emulsifi cation process, the physical characteristics of the fi ve cream formulas, including organoleptic, homogeneity, emulsion type, pH, adhesion, specifi c gravity, viscosity, and stability were evaluated. Formula 3 (F3), cream formulation with 6% cetyl alcohol having physical characteristics of a white homogeneous cream with a pronounced lemongrass scent, emulsion type o/w, pH of 6.30 ± 0.02, adhesion of 16.85 ± 0.58 s, a specifi c gravity of 1.031 ± 0.009 g/mL, and viscosity of 4418 ± 182 m Pas was chosen as the optimized formula. F3 was then subjected to antibacterial testing against P. acne and showed a 9.35 mm inhibition zone. Cream-based citronella oil, therefore, becomes a promising preparation for acne treatment","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Drug Delivery Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25258/ijddt.13.1.67","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 0

Abstract

Acne is a prevalent skin disorder that aff ects 80–85% of teenagers globally. Citronella oil is one of the natural compounds that has been known to potentially treat acne, but its application is limited due to its greasiness and uncomfortable sensation on skin. This study aimed to optimize the concentration of cetyl alcohol as a viscosity enhancer that can produce a physically stable cream preparation and to evaluate the antibacterial activity of the optimized formula against Propionibacterium acnes. Following the emulsifi cation process, the physical characteristics of the fi ve cream formulas, including organoleptic, homogeneity, emulsion type, pH, adhesion, specifi c gravity, viscosity, and stability were evaluated. Formula 3 (F3), cream formulation with 6% cetyl alcohol having physical characteristics of a white homogeneous cream with a pronounced lemongrass scent, emulsion type o/w, pH of 6.30 ± 0.02, adhesion of 16.85 ± 0.58 s, a specifi c gravity of 1.031 ± 0.009 g/mL, and viscosity of 4418 ± 182 m Pas was chosen as the optimized formula. F3 was then subjected to antibacterial testing against P. acne and showed a 9.35 mm inhibition zone. Cream-based citronella oil, therefore, becomes a promising preparation for acne treatment

查看原文本刊更多论文

香茅油的制备及评价痤疮治疗霜

痤疮是一种普遍的皮肤病，影响着全球80-85%的青少年。香茅油是一种天然化合物，已知有潜在的治疗痤疮，但其应用是有限的，因为它的油脂和不舒服的感觉在皮肤上。本研究旨在优化十六烷基醇作为黏度增强剂的浓度，以制备物理稳定的乳膏制剂，并评价优化后的配方对痤疮丙酸杆菌的抗菌活性。在乳化过程中，评估了五种乳膏配方的物理特性，包括感官、均匀性、乳液类型、pH、附着力、比重、粘度和稳定性。选择公式3 (F3)中添加6%十六醇的乳膏物理特性为白色均匀乳膏，具有明显的柠檬草香味，乳液类型为0 /w, pH为6.30±0.02，附着力为16.85±0.58 s，比重为1.031±0.009 g/mL，粘度为4418±182 m Pas为优化配方。F3对痤疮P.痤疮有9.35 mm的抑制带。霜基香茅油，因此，成为一个有前途的准备痤疮治疗

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Drug Delivery Technology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： International Journal of Drug Delivery Technology (IJDDT) provides the forum for reporting innovations, production methods, technologies, initiatives and the application of scientific knowledge to the aspects of pharmaceutics, including controlled drug release systems, drug targeting etc. in the form of expert forums, reviews, full research papers, and short communications.