A case of lower limbs infection caused by Helcococcus Kunzii and literature analysis

中国综合临床 Pub Date : 2019-07-01 DOI:10.3760/CMA.J.ISSN.1008-6315.2019.04.002

Yasi Wang, Ai-ling Dong, Yubing Fu, Lei Zhang, Junzhi Huang, H. Xing, Nanyu Wang

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Abstract

Objective To describe a case of lower limbs infection of Helcococcus Kunzii in North China University of Science and Technology Affiliated Hospital in October 2017 and to analyze the etiology and drug susceptibility. Methods The bacteria were identified by French Meriere mass spectrometer and BD Phoenix-100 automatic bacterial identification/drug sensitivity system.The drug resistance of the bacteria was detected by disk diffusion method, and collected the clinical information and related literature information of the Helcococcus Kunzi to analyze. Results The Gram-positive cocci was isolated from the foot secretion of a patient with venous thrombosis of lower limbs complicated with infection.The result of smear was Gram-positive cocci in double, agglomerate and varied in size.On the blood plate, there was a small colony of α hemolysis.Thixozyme negative, β galactosidase negative.The results of mass spectrometry identification and two kinds of fully automatic bacterial identification / drug sensitivity system were identified as Helcococcus Kunzii, the isolates was resistant to erythromycin and clindamycin among the 10 antibiotics tested.By searching, sorting out and analyzing the literature information, it is revealed that the infection of this bacterium is not related to sex.Middle-aged and elderly people are mostly infected.And the cocci easily infected patients with lower immunity.The infection of lower limbs is 47.37%, the infection of blood flow is 15.79% and the other ways of infection are 42.11% (lung, mammary gland, etc.). Conclusion Helcococcus Kunzii is a conditional pathogen, and patients with lower immunity are more common.Erythromycin resistance could identify it from the green balloon bacteria.Moreover, the bacteria could cause a wide spectrum of diseases, and easily cause sepsis and lower limbs infections, which reminds us that we should be vigilant in clinical practice. Key words: Helcococcus Kunzii; Lower limb infection; Mass spectrometry identification; Drug resistance detection

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昆明紫茧菌致下肢感染1例并文献分析

目的描述2017年10月华北科技大学附属医院收治的1例昆子Helcococcus Kunzii下肢感染病例，分析其病因及药敏情况。方法采用法国Meriere质谱仪和BD Phoenix-100全自动细菌鉴定/药敏系统进行细菌鉴定。采用纸片扩散法检测该菌的耐药性，并收集昆子Helcococcus Kunzi的临床资料和相关文献资料进行分析。结果从一例下肢静脉血栓形成合并感染患者的足部分泌物中分离到革兰氏阳性球菌。涂片结果为革兰氏阳性球菌，呈双球菌、聚集性，大小不等。在血板上，有一个小的α溶血菌落。Thixozyme阴性，β半乳糖苷酶阴性。质谱鉴定和两种全自动细菌鉴定/药敏系统鉴定结果均为昆子Helcococcus Kunzii，在10种抗生素中，分离株对红霉素和克林霉素具有耐药性。通过对文献资料的检索、整理和分析，发现该菌的感染与性别无关。中老年人大多受到感染。而球菌易感染免疫力较低的患者。下肢感染占47.37%，血流感染占15.79%，其他感染途径（肺、乳腺等）占42.11%。红霉素耐药性可以从绿气球细菌中鉴定出来。此外，该细菌可引起广泛的疾病，并容易引起败血症和下肢感染，这提醒我们在临床实践中应提高警惕。关键词：昆子Helcococcus Kunzii；下肢感染；质谱鉴定；耐药性检测

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来源期刊

中国综合临床

CiteScore

0.10

自引率

0.00%

发文量

16855

期刊介绍： Clinical Medicine of China is an academic journal organized by the Chinese Medical Association (CMA), which mainly publishes original research papers, reviews and commentaries in the field. Clinical Medicine of China is a source journal of Peking University (2000 and 2004 editions), a core journal of Chinese science and technology, an academic journal of RCCSE China Core (Extended Edition), and has been published in Chemical Abstracts of the United States (CA), Abstracts Journal of Russia (AJ), Chinese Core Journals (Selection) Database, Chinese Science and Technology Materials Directory, Wanfang Database, China Academic Journal Database, JST Japan Science and Technology Agency Database (Japanese) (2018) and other databases.