{"title":"N-Heterocyclic carbene complexes of Au(I), Ag(I), and Cu(I) as potential anticancer agents: a review","authors":"Abdullah Alsalhi","doi":"10.1080/00958972.2023.2219369","DOIUrl":null,"url":null,"abstract":"Abstract The discovery of cisplatin antitumor properties in 1969 encouraged researchers to design metal-based anticancer drugs. Recently, research on N-heterocyclic carbene-based metal complexes was successful due to their excellent anticancer potency and other biological activities, for example antitubercular, antiviral, anti-ulcerogenic, antifungal, antiglycation antimalarial, anti-inflammatory, antineuropathic, antihypertensive, antioxidant, anti-obesity, antibacterial, and analgesic activity. These complexes have excellent anticancer activities, even higher than cisplatin. Herein, we summarize the anticancer activities of N-heterocyclic carbene (NHC) based metal complexes of Au(I), Ag(I), and Cu(I). Further, the mechanism of action and the possible structure-activity relationships (SAR) are discussed. We hope this article will help researchers in designing highly potent Au(I), Ag(I), and Cu(I)-N-heterocyclic carbene complexes for the possible treatment of various types of cancer.","PeriodicalId":15421,"journal":{"name":"Journal of Coordination Chemistry","volume":"76 1","pages":"847 - 861"},"PeriodicalIF":2.2000,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Coordination Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/00958972.2023.2219369","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract The discovery of cisplatin antitumor properties in 1969 encouraged researchers to design metal-based anticancer drugs. Recently, research on N-heterocyclic carbene-based metal complexes was successful due to their excellent anticancer potency and other biological activities, for example antitubercular, antiviral, anti-ulcerogenic, antifungal, antiglycation antimalarial, anti-inflammatory, antineuropathic, antihypertensive, antioxidant, anti-obesity, antibacterial, and analgesic activity. These complexes have excellent anticancer activities, even higher than cisplatin. Herein, we summarize the anticancer activities of N-heterocyclic carbene (NHC) based metal complexes of Au(I), Ag(I), and Cu(I). Further, the mechanism of action and the possible structure-activity relationships (SAR) are discussed. We hope this article will help researchers in designing highly potent Au(I), Ag(I), and Cu(I)-N-heterocyclic carbene complexes for the possible treatment of various types of cancer.
期刊介绍:
The Journal of Coordination Chemistry publishes the results of original investigations of coordination complexes, loosely defined as the interactions of organic or inorganic ligands with metal centres. Original investigations may involve syntheses, structures, physical and chemical properties, kinetics and mechanisms of reactions, calculations and applications of coordination compounds. The applications may involve bioinorganic, organometallic, catalytic, solid state/materials, coordination chemistry of nanostructured surfaces and medicinal studies.
The Journal publishes original manuscripts, communications and reviews. Original manuscripts are expected to provide a clear contribution to the advance of coordination chemistry. Communications are short manuscripts with an urgency that requires rapid publication. Reviews are welcome in all areas of coordination chemistry and may focus on the metal, ligand or applications. Reviews of emerging areas of coordination chemistry should be developed fully from the basics, carefully relating the topic to the field in general. Reviews of well established subjects should collect developments from the literature and take a critical view of recent work.