Neurodegeneration- Disease And Dementia

Abstract

Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), front temporal dementia (FTD) and Huntington’s disease (HD show some clinical, morbid and molecular overlapping [1]. PD is one of the most common neurodegenerative disorders. Dopaminergic neurons in the substantia nigra pars compacta degenerate and die, which forms the basis of the disease [2]. As the disease intensifies with the passage of time, many people develop dementia, and other mental abilities in later stages [3]. Loss of dopaminergic neurons causes prominent and projecting symptoms like involuntary tremor, rigidity, postural instability, gait, speech problems and akinesia [4]. One accepted and efficient convention for generating dopaminergic neurons in vitro is the combination of several pharmacological compounds and molecules. A broad general evaluation of neurodegeneration is discussed in this article.