Potensi katekin daun gambir (uncaria gambier roxb.) sebagai agen pembekuan darah pasca ekstraksi gigiPotential the catechins of the gambier leaf (uncaria gambier roxb.) as agen blood clotting after tooth extraction

Abstract

Introduction : Tooth extraction is one of the common procedures in dentistry that dentists often perform. Tooth extraction can cause complications, one of which is bleeding. The gambier plant is a native Indonesian plant whose utilization is still rare and has the potential to accelerate blood clotting. Gambier plants contain catechins, a group of flavonoids that can maintain the permeability of blood vessels. This study aimed to analyze the potential of gambir catechins as agents to accelerate blood clotting after tooth extraction. Methods : This research was a quasi-experimental study with a sample of 16 people. Before being tested with blood, gambier catechins were made from gambier leaves and extracted using the maceration method. The test was carried out using human blood with blood types A, B, AB, and O with five treatments each, namely positive control with tranexamic acid, negative control without treatment, gambir catechin extract with a concentration of 25, 35, and 45%. Result : The data that has been obtained is normally distributed and shows that the results of the one-way test ANOVA treatment of gambir leaf catechin extract for each blood group showed results significant (p=0.0005). The results of the post hoc test showed that there were differences in the significance value for each treatment group for each blood group. Conclusion : Catechin extract from gambir leaves can accelerate the process of blood clotting, especially with a concentration of 45%. Hence, it has the potential as an agent to accelerate clotting after tooth extraction.