Effectiveness and safety of Korean medicine for pain management after musculoskeletal surgery: a retrospective study

IF 1.8 Q3 PHARMACOLOGY & PHARMACY
Hansol Lee, Hyungsuk Kim, Koh-Woon Kim, Jae-Heung Cho, Mi-Yeon Song, Won-Seok Chung
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Abstract

To assess the effectiveness and safety of Korean medicine in managing postoperative pain. Retrospective, observational study. Medical records of 233 inpatients at a Korean medicine hospital who underwent Korean medicine treatments such as acupuncture, moxibustion, cuppping, bee-venom and herbal acupuncture, electrical therapy, herbal medicine, and carbon-beam therapy after musculoskeletal surgery were reviewed, and numeric ratings for pain were compared between baseline and follow-up. A correlation analysis between pain improvement and therapeutic factors was performed, and a regression analysis was conducted to determine the predictors of pain reduction. Serum laboratory test results at baseline and follow-up were subsequently compared to identify safety. Numeric rating scale scores for pain; presence of infection, drug-induced liver injury (DILI), and drug-induced kidney injury (DIKI) for safety. After Korean medicine treatment, the pain scores decreased from an average of 4.09 to 1.79 in the numeric rating scale (p < 0.001). Frequency of acupuncture therapy during hospitalization showed the strongest positive correlation with pain improvement (r = 0.341, p = 0.000) and was a predictor of pain reduction (adjusted R2 = 0.145). Improvements in serum laboratory data to reference limits were observed. All kappa coefficient values, except for white blood cell (WBC) count, were between 0.3 and 0.7, indicating that the follow-up data matched the baseline data. The low kappa coefficient value of WBC count was due to the high ratio of outliers. One (0.43%) and no cases of DILI and DIKI were identified, respectively. Korean medicine could be used for managing pain after musculoskeletal surgery.

韩国药物用于肌肉骨骼手术后疼痛管理的有效性和安全性:一项回顾性研究
目的:评价韩药治疗术后疼痛的有效性和安全性。回顾性观察性研究。对在某韩医医院接受针灸、艾灸、拔罐、蜂毒和草药针灸、电疗、草药、碳束疗法等韩医治疗的233名住院患者的病历进行了分析,并比较了基线和随访期间的疼痛数值评分。对疼痛改善与治疗因素进行相关性分析,并进行回归分析以确定疼痛减轻的预测因素。随后将基线和随访时的血清实验室检测结果进行比较以确定安全性。疼痛的数值评定量表得分;存在感染、药物性肝损伤(DILI)和药物性肾损伤(DIKI)的安全性。经韩药治疗后,疼痛评分从平均4.09分降至1.79分(p < 0.001)。住院期间针灸治疗频率与疼痛改善呈最强正相关(r = 0.341, p = 0.000),是疼痛减轻的预测因子(校正R2 = 0.145)。观察到血清实验室数据达到参考值的改善。除白细胞(WBC)计数外,所有kappa系数值均在0.3 ~ 0.7之间,表明随访数据与基线数据相符。白细胞计数kappa系数值低是由于异常值比例高。DILI 1例(0.43%),DIKI 1例(0.43%);韩国医学可以用来缓解肌肉骨骼手术后的疼痛。
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来源期刊
Advances in Traditional Medicine
Advances in Traditional Medicine PHARMACOLOGY & PHARMACY-
CiteScore
4.30
自引率
0.00%
发文量
50
期刊介绍: Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.
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