Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy

IF 13.4 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Nano Convergence Pub Date : 2023-08-07 DOI:10.1186/s40580-023-00385-3

Jieun Han, Jaesung Lim, Chi-Pin James Wang, Jun-Hyeok Han, Ha Eun Shin, Se-Na Kim, Dooyong Jeong, Sang Hwi Lee, Bok-Hwan Chun, Chun Gwon Park, Wooram Park

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引用次数: 1

Abstract

Cancer immunotherapy, which harnesses the power of the immune system, has shown immense promise in the fight against malignancies. Messenger RNA (mRNA) stands as a versatile instrument in this context, with its capacity to encode tumor-associated antigens (TAAs), immune cell receptors, cytokines, and antibodies. Nevertheless, the inherent structural instability of mRNA requires the development of effective delivery systems. Lipid nanoparticles (LNPs) have emerged as significant candidates for mRNA delivery in cancer immunotherapy, providing both protection to the mRNA and enhanced intracellular delivery efficiency. In this review, we offer a comprehensive summary of the recent advancements in LNP-based mRNA delivery systems, with a focus on strategies for optimizing the design and delivery of mRNA-encoded therapeutics in cancer treatment. Furthermore, we delve into the challenges encountered in this field and contemplate future perspectives, aiming to improve the safety and efficacy of LNP-based mRNA cancer immunotherapies.

Graphical Abstract

查看原文本刊更多论文

基于脂质纳米颗粒的mRNA传递系统用于癌症免疫治疗

癌症免疫疗法利用免疫系统的力量，在对抗恶性肿瘤方面显示出巨大的希望。信使RNA (mRNA)具有编码肿瘤相关抗原(TAAs)、免疫细胞受体、细胞因子和抗体的能力，是一种多功能工具。然而，mRNA固有的结构不稳定性要求开发有效的递送系统。脂质纳米颗粒(LNPs)已成为癌症免疫治疗中mRNA递送的重要候选者，既可以保护mRNA，又可以提高细胞内递送效率。在这篇综述中，我们全面总结了基于lnp的mRNA递送系统的最新进展，重点介绍了在癌症治疗中优化mRNA编码疗法的设计和递送的策略。此外，我们深入研究了该领域遇到的挑战，并展望了未来的前景，旨在提高基于lnp的mRNA癌症免疫治疗的安全性和有效性。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano Convergence Engineering-General Engineering

CiteScore

15.90

自引率

2.60%

发文量

审稿时长

13 weeks

期刊介绍： Nano Convergence is an internationally recognized, peer-reviewed, and interdisciplinary journal designed to foster effective communication among scientists spanning diverse research areas closely aligned with nanoscience and nanotechnology. Dedicated to encouraging the convergence of technologies across the nano- to microscopic scale, the journal aims to unveil novel scientific domains and cultivate fresh research prospects. Operating on a single-blind peer-review system, Nano Convergence ensures transparency in the review process, with reviewers cognizant of authors' names and affiliations while maintaining anonymity in the feedback provided to authors.