Bioinformatics Evaluation of SPATA19 Gene Expression in Different Parts of Brain

Mahsa Zargar, S. Majidian, M. Modarressi, S. Shabani
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Abstract

Background: Determining the expression pattern of testis genes in the brain is essential for understanding tissue functions and correlation or inter-correlation between testis and the brain. In this study, we examined spermatogenesis-associated 19 (SPATA19 gene) expression in 10 parts of the brain with bioinformatics analysis. Materials and Methods: The public dataset GSE46706, including 1231 samples originated from 134 Caucasian individuals, was downloaded from NCBI Gene Expression Omnibus (GEO). SPATA19 gene expression in the cerebellar cortex, frontal cortex, hippocampus, medulla, occipital cortex, putamen, substantia nigra, temporal cortex, thalamus, and white matter was examined against each other using R software and the t-test. Results: Out of 10 brain parts examined, the cerebellar cortex and white matter showed the highest expression, and the temporal cortex showed the lowest expression of the gene. So the cerebellar cortex had a 5.6% and 6.2% increase in gene expression relative to the putamen and temporal cortex with P values of 6.04e-13 and 2.15e-17, respectively. Also, the white matter had a 4% increase in gene expression over the temporal cortex with a P value of 1.89e-13. Conclusion: SPATA19 had more expression in the cerebellar cortex and white matter than other brain parts. These two parts make up the cerebellum.
SPATA19基因在大脑不同部位表达的生物信息学评价
背景:确定睾丸基因在大脑中的表达模式对于理解组织功能以及睾丸与大脑之间的相关性或相互关系至关重要。在本研究中,我们通过生物信息学分析检测了大脑10个部位的精子发生相关19(SPATA19基因)表达。材料和方法:公共数据集GSE46706,包括来自134名高加索个体的1231个样本,从NCBI基因表达综合数据库(GEO)下载。SPATA19基因在小脑皮层、额叶皮层、海马、髓质、枕叶皮层、壳核、黑质、颞叶皮层、丘脑和白质中的表达使用R软件和t检验进行对照。结果:在检查的10个大脑部分中,小脑皮层和白质的基因表达最高,颞叶皮层的基因表达最低。因此,相对于壳核和颞叶皮层,小脑皮层的基因表达分别增加了5.6%和6.2%,P值分别为6.04e-13和2.15e-17。此外,在颞叶皮层上,白质的基因表达增加了4%,P值为1.89e-13。结论:SPATA19在小脑皮质和白质中的表达高于其他脑区。这两个部分组成小脑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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