Remineralizing Agents in the Prevention of Caries: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Q3 Dentistry

Journal of Orofacial Sciences Pub Date : 2021-07-01 DOI:10.4103/jofs.jofs_235_21

D. Vasamsetti, Srinivas Pachava, Devaki Talluri

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引用次数: 0

Abstract

Introduction: The systematic review presented here aims to determine and find out the clinical efficacy of various remineralization agents for early enamel caries. Materials and methods: An aggregate of 240 articles has been retrieved from PubMed, Cochrane Library, Trip, and Google scholarly databases from 2010 to 2020, of which 18 randomized controlled trials (RCTs) have been integrated into this systematic review, and six of which were considered for meta-analysis. The risk of bias in each study was evaluated using the Cochrane collaboration’s tool. Results: Ten of the 18 studies suggest that carious lesions are successfully minimized by remineralization. Four studies showed superior efficacy of casein phosphopeptide and amorphous calcium phosphate (CPP-ACP) in the remineralization of white spot lesions. There was no statistically significant difference (standard mean difference = −0.18, 95% confidence interval: −0.48 to 0.12, P = 0.23) between the experimental and control groups. Conclusion: This review has demonstrated an absence of dependable proof supporting the clinical adequacy of remineralizing agents. Therefore, RCTs in well-designed forms are needed to enhance all sorts of evidence in this field.

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再矿化剂预防龋齿:随机对照试验的系统回顾和荟萃分析

前言:本系统综述旨在确定和了解各种再矿化剂治疗早期牙釉质龋的临床疗效。材料和方法:从PubMed、Cochrane Library、Trip和谷歌学术数据库中检索到2010年至2020年的240篇文章，其中18篇随机对照试验(rct)被纳入本系统综述，其中6篇被纳入meta分析。每项研究的偏倚风险使用Cochrane协作工具进行评估。结果:18项研究中有10项表明，再矿化可以成功地减少龋齿病变。四项研究显示酪蛋白磷酸肽和无定形磷酸钙(CPP-ACP)对白斑病变再矿化有较好的疗效。实验组与对照组间差异无统计学意义(标准均值差= - 0.18,95%可信区间:- 0.48 ~ 0.12,P = 0.23)。结论:本综述显示缺乏可靠的证据支持再矿化药物的临床充分性。因此，需要设计良好的随机对照试验来增强该领域的各种证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Orofacial Sciences Dentistry-Orthodontics

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

31 weeks

期刊介绍： Journal of Orofacial Sciences is dedicated to noblest profession of Dentistry, and to the young & blossoming intellects of dentistry, with whom the future of dentistry will be cherished better. The prime aim of this journal is to advance the science and art of dentistry. This journal is an educational tool to encourage and share the acquired knowledge with our peers. It also to improves the standards and quality of therauptic methods. This journal assures you to gain knowledge in recent advances and research activities. The journal publishes original scientific papers with special emphasis on research, unusual case reports, editorial, review articles, book reviews & other relevant information in context of high professional standards.