Phytotherapeutics of Vicia faba L. in Parkinson’s Disease: An in silico Approach

Q2 Social Sciences

Studies on Ethno-Medicine Pub Date : 2022-09-15 DOI:10.31901/24566772.2022/16.3-4.656

A. Anand

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Abstract

Vicia faba L. has a major role in the traditional diet and medicinal system of different countries. V. faba is a natural source of the precursor of dopamine (Levodopa) which is used treatment of Parkinson’s disease. The objective of the study is to investigate the in vitro antioxidant capacity, Gas Chromatography-Mass Spectrometry and docking of V. faba against Parkinson’s disease. The values indicated that acetone and aqueous extract exhibited a higher value of total phenolic and flavonoid contents respectively. The results of the 2, 2- diphenyl-1- picrylhydrazyl free radical scavenging assay and ferric reducing antioxidant power assay displayed that aqueous extract had better radical scavenging activity. In the 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonate) radical scavenging assay, ethanolic extract showed a lower Inhibitory Concentration50 value. In silico analysis indicated that the phyto-compounds present in V. faba has a higher binding affinity to the dopamine1 receptor. The results suggested that V. faba has good antioxidant properties and can be used as a dopamine agonist for the dopamine1 receptor which may be useful in combating Parkinson’s disease.

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蚕豆对帕金森病的植物治疗：一种硅方法

蚕豆在各国的传统饮食和医药体系中占有重要地位。蚕豆是用于治疗帕金森病的多巴胺前体（左旋多巴）的天然来源。本研究的目的是研究蚕豆对帕金森病的体外抗氧化能力、气相色谱-质谱和对接。结果表明，丙酮和水提取物的总酚和黄酮含量分别较高。2，2-二苯基-1-苦基肼自由基清除试验和铁还原抗氧化能力试验结果表明，水提物具有较好的自由基清除活性。在2,2-锌双（3-乙基苯并噻唑啉-6-磺酸酯）自由基清除测定中，乙醇提取物显示出较低的抑制浓度50值。计算机分析表明，蚕豆中存在的植物化合物对多巴胺1受体具有更高的结合亲和力。结果表明，蚕豆具有良好的抗氧化特性，可作为多巴胺1受体的多巴胺激动剂，这可能有助于对抗帕金森病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Studies on Ethno-Medicine Social Sciences-Cultural Studies

CiteScore

0.50

自引率

0.00%

发文量

期刊介绍： Studies on Ethno-Medicine is a peer reviewed, internationally circulated journal. It publishes reports of original research, theoretical articles, timely reviews, brief communications, book reviews and other publications in the interdisciplinary field of ethno-medicine. The journal serves as a forum for physical, social and life scientists as well as for health professionals. The transdisciplinary areas covered by this journal include, but are not limited to, Physical Sciences, Anthropology, Sociology, Geography, Life Sciences, Environmental Sciences, Botany, Agriculture, Home Science, Zoology, Genetics, Biology, Medical Sciences, Public Health, Demography and Epidemiology. The journal publishes basic, applied and methodologically oriented research from all such areas. The journal is committed to prompt review, and priority publication is given to manuscripts with novel or timely findings, and to manuscript of unusual interest. Further, the manuscripts are categorised under three types, namely - Regular articles, Short Communications and Reviews. The researchers are invited to submit original papers in English (papers published elsewhere or under consideration elsewhere shall not be considered).