Sociodemographic Factors, Nutritional Status, and Inflammatory Markers in Patients with Postural Orthostatic Tachycardia Syndrome

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Acta Neurologica Scandinavica Pub Date : 2023-03-17 DOI:10.1155/2023/3992718

Hanna Tufvesson, V. Hamrefors, B. Roth, A. Fedorowski, B. Ohlsson

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引用次数: 1

Abstract

Objectives. Postural orthostatic tachycardia syndrome (POTS) is characterized by cardiovascular autonomic dysfunction of unknown etiology with high a prevalence of gastrointestinal symptoms. The aim of the present study was to examine sociodemographic, lifestyle, and nutritional factors as well as inflammatory markers in patients with POTS. Materials and Methods. Forty-three patients with POTS and 61 healthy controls completed questionnaires about sociodemographic factors, lifestyle habits, and gastrointestinal symptoms. Blood samples were analyzed for serum levels of cobalamins, folic acid, iron, total iron-binding capacity (TIBC), ferritin, sodium, potassium, magnesium, phosphorus, albumin, high-sensitive C-reactive protein (CRP), and 25-hydroxyvitamin D (25-OH vitamin D). Results. POTS patients were predominantly women with a lower education level and were more often working part-time, on sick leave, and living alone compared with healthy controls. They reported lower alcohol intake and physical activity levels than controls. The nutrient intake was in general similar in both groups, but POTS patients had a higher intake of different drinks and reported more gastrointestinal symptoms than controls. POTS was associated with higher CRP levels (β: 1.370; 95% CI: 0.004–2.737; p = 0.049 ), lower albumin levels (β: -1.443; 95% CI: -2.648–(-0.238); p = 0.019 ), and higher sodium levels (β: 1.392; 95% CI: 0.559–2.225; p = 0.001 ). Abdominal pain ( p = 0.004 ) and intestinal symptoms’ influence on daily life ( p = 0.025 ) were negatively associated with albumin levels. Abdominal pain ( p = 0.011 ), vomiting and nausea ( p = 0.003 ), and intestinal symptoms’ influence on daily life ( p = 0.026 ) were associated with higher sodium levels. Serum levels representing iron and vitamin metabolism were equal between groups. Conclusions. POTS is associated with poorer sociodemographic status, but malnutrition cannot explain POTS or related gastrointestinal symptoms. Higher CRP and lower albumin levels suggest low-grade inflammation as one possible etiological factor.

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体位性心动过速综合征患者的社会人口因素、营养状况和炎症标志物

目标。体位性站立性心动过速综合征(POTS)的特点是病因不明的心血管自主神经功能障碍，并伴有高发生率的胃肠道症状。本研究的目的是检查社会人口统计学、生活方式、营养因素以及POTS患者的炎症标志物。材料与方法。43名POTS患者和61名健康对照者完成了关于社会人口因素、生活习惯和胃肠道症状的问卷调查。分析血液样本血清中钴胺素、叶酸、铁、总铁结合能力(TIBC)、铁蛋白、钠、钾、镁、磷、白蛋白、高敏c反应蛋白(CRP)和25-羟基维生素D (25-OH维生素D)的水平。POTS患者主要是受教育程度较低的妇女，与健康对照组相比，她们更多的是兼职工作、请病假和独居。与对照组相比，他们的酒精摄入量和体力活动水平都较低。两组的营养摄入量大致相似，但POTS患者摄入不同饮料的量更高，并且报告的胃肠道症状比对照组更多。POTS与CRP水平升高相关(β: 1.370;95% ci: 0.004-2.737;P = 0.049)，白蛋白水平较低(β: -1.443;95% ci: -2.648 (-0.238);P = 0.019)和较高的钠水平(β: 1.392;95% ci: 0.559-2.225;P = 0.001)。腹痛(p = 0.004)和肠道症状对日常生活的影响(p = 0.025)与白蛋白水平呈负相关。腹痛(p = 0.011)、呕吐和恶心(p = 0.003)以及肠道症状对日常生活的影响(p = 0.026)与高钠水平相关。两组之间的血清铁和维生素代谢水平相等。结论。POTS与较差的社会人口状况有关，但营养不良不能解释POTS或相关胃肠道症状。较高的CRP和较低的白蛋白水平提示低度炎症是一个可能的病因。

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来源期刊

Acta Neurologica Scandinavica 医学-临床神经学

CiteScore

6.70

自引率

2.90%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Acta Neurologica Scandinavica aims to publish manuscripts of a high scientific quality representing original clinical, diagnostic or experimental work in neuroscience. The journal''s scope is to act as an international forum for the dissemination of information advancing the science or practice of this subject area. Papers in English will be welcomed, especially those which bring new knowledge and observations from the application of therapies or techniques in the combating of a broad spectrum of neurological disease and neurodegenerative disorders. Relevant articles on the basic neurosciences will be published where they extend present understanding of such disorders. Priority will be given to review of topical subjects. Papers requiring rapid publication because of their significance and timeliness will be included as ''Clinical commentaries'' not exceeding two printed pages, as will ''Clinical commentaries'' of sufficient general interest. Debate within the speciality is encouraged in the form of ''Letters to the editor''. All submitted manuscripts falling within the overall scope of the journal will be assessed by suitably qualified referees.