Trajectory of the spectral/structural rearrangements for photo-oxidative reaction of neat ketoprofen and its cyclodextrin complex

IF 2.3 4区化学 Q2 Agricultural and Biological Sciences

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2022-09-06 DOI:10.1007/s10847-022-01160-3

Ryosuke Hiroshige, Satoru Goto, Chihiro Tsunoda, Risa Ichii, Shota Shimizu, Yuta Otsuka, Kosho Makino, Hideyo Takahashi, Hideshi Yokoyama

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引用次数: 2

Abstract

Ketoprofen is a nonsteroidal anti-inflammatory drug used as mohrus tape which causes unwanted photosensitivity due to UV irradiation. In addition, photodegradation of ketoprofen induces its decarboxylation. Here, we aim to determine the effect of cyclodextrin on the photolysis of ketoprofen. Separation technique using HPLC confirmed that UV irradiation of ketoprofen produced multiple products. A unique reaction proceeded in the presence of β-cyclodextrin. Furthermore, characterization by UV spectroscopy was performed, and the obtained spectra were analyzed using singular value decomposition. By analyzing the trajectory of the singular vector space, we were able to reflect the difference in the reaction pathway of ketoprofen with and without cyclodextrin. This study uses a singular value decomposition analysis, which is useful as a novel approach for solutions of radical reactions and a promising technique for analysis of radical reactions in the future.

Graphical abstract

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纯酮洛芬及其环糊精配合物光氧化反应的光谱/结构重排轨迹

酮洛芬是一种非甾体抗炎药，用作莫氏胶带，由于紫外线照射会引起不必要的光敏性。此外，酮洛芬的光降解诱导其脱羧。本文旨在研究环糊精对酮洛芬光解的影响。HPLC分离技术证实了酮洛芬在紫外照射下可产生多种产物。在β-环糊精存在下进行了独特的反应。利用紫外光谱进行表征，并利用奇异值分解对所得光谱进行分析。通过分析奇异向量空间的轨迹，我们可以反映出含环糊精和不含环糊精的酮洛芬反应途径的差异。本研究采用了奇异值分解分析方法，为自由基反应的解提供了一种新的方法，并为今后的自由基反应分析提供了一种很有前途的技术。图形抽象

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来源期刊

Journal of Inclusion Phenomena and Macrocyclic Chemistry 化学-化学综合

CiteScore

3.30

自引率

8.70%

发文量

审稿时长

3-8 weeks

期刊介绍： The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.