Cognitive Function in Type 2 Diabetes Mellitus Patients Taking Metformin and Metformin-Sulfonylurea

IF 0.4 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Abu Rachman, R. Sauriasari, N. F. Syafhan, P. Prawiroharjo, H. W. Risni
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引用次数: 0

Abstract

The most prescribed antidiabetic drugs in Indonesian primary health care are metformin or a combination of metformin and sulfonylurea. Studies on metformin have shown various impacts on cognitive decline in patients with type 2 diabetes mellitus, whereas sulfonylurea has been shown to reduce this impact. This study aimed to compare the impacts of metformin and metformin-sulfonylurea on cognitive function and determine what factors affected it. This cross-sectional study was conducted at Pasar Minggu Primary Health Care involving 142 type 2 diabetes mellitus patients taking metformin or metformin-sulfonylurea for > 6 months and aged > 36 years. Cognitive function was assessed using the validated Montreal Cognitive Assessment Indonesian version. The effects of metformin and metformin-sulfonylurea on cognitive decline showed no significant difference, even after controlling for covariates (aOR = 1.096; 95% CI = 0.523–2.297; p-value = 0.808). Multivariate analysis showed age (OR = 4.131; 95% CI = 1.271–13.428; p-value = 0.018) and education (OR = 2.746; 95% CI = 1.196–6.305; p-value = 0.017) affected cognitive function. Since a lower education and older age are likely to cause cognitive decline, health professionals are encouraged to work with public health experts to address these risk factors for cognitive function.
二甲双胍和二甲双胍磺酰脲对2型糖尿病患者认知功能的影响
印尼初级卫生保健中处方最多的抗糖尿病药物是二甲双胍或二甲双胍和磺酰脲的组合。二甲双胍的研究表明,二甲双胍对2型糖尿病患者认知能力下降有多种影响,而磺酰脲类药物已被证明可以减少这种影响。本研究旨在比较二甲双胍和二甲双胍磺酰脲对认知功能的影响,并确定影响认知功能的因素。本横断面研究在帕萨明古初级卫生保健中心进行,涉及142名服用二甲双胍或二甲双胍磺酰尿素超过6个月且年龄超过36岁的2型糖尿病患者。认知功能使用经验证的蒙特利尔认知评估印尼版进行评估。即使在控制协变量后,二甲双胍和二甲双胍磺酰脲对认知能力下降的影响也没有显著差异(aOR=1.096;95%CI=0.523-2.297;p值=0.808)。多变量分析显示,年龄(OR=4.31;95%CI=1.271-13.428;p值=0.018)和教育程度(OR=2.746;95%CI=1.196-6.305;p值0.017)影响认知功能。由于教育程度较低和年龄较大可能导致认知能力下降,因此鼓励卫生专业人员与公共卫生专家合作,解决认知功能的这些风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Kesmas-National Public Health Journal
Kesmas-National Public Health Journal PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
1.70
自引率
0.00%
发文量
39
审稿时长
10 weeks
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