Research progress in multifunctional nanomedicine for the combination of tumor chemotherapy and immunotherapy

Shurui Ma, Hangtian Zhang, Hongyang Chen, Q. He, Xing-long Li, Danhui Hu, Quanxin Li
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Abstract

Although the combination of surgery, radiotherapy and chemotherapy is the main methods of cancer treatment, it still fails to solve certain tumors, especially metastatic tumors. With the in-depth study of tumorigenesis and development mechanism, and the exploration and clinical application of tumor immunotherapy, the survival period of patients with malignant tumors has been significantly prolonged. Tumor immunotherapy has become an effective anti-tumor method by activating the body′s own immune system to achieve tumor suppression. The combination of chemotherapy and immunotherapy has a significant effect and has become a feasible solution for cancer treatment. The rationally designed nanomedicines can effectively combine chemical drugs and immunological preparations, and have become an effective delivery carrier basis and treatment means for clinically targeting tumor tissues, synergistic immune mechanisms to kill tumor cells, and treating tumors. In this paper, the types of multifunctional nanomedicines used in chemotherapy and various immunotherapies in recent years and their advantages in cancer therapy were reviewed. Key words: Nanomedicine; Cancer therapy; Immunotherapy; Chemotherapy; Combined treatment
肿瘤化疗与免疫联合治疗的多功能纳米药物研究进展
虽然手术、放疗和化疗相结合是癌症治疗的主要方法,但它仍然无法解决某些肿瘤,尤其是转移性肿瘤。随着对肿瘤发生发展机制的深入研究,以及肿瘤免疫治疗的探索和临床应用,恶性肿瘤患者的生存期显著延长。肿瘤免疫疗法通过激活人体自身免疫系统来实现肿瘤抑制,已成为一种有效的抗肿瘤方法。化疗与免疫治疗相结合具有显著效果,已成为癌症治疗的可行方案。合理设计的纳米药物可以将化学药物和免疫制剂有效结合,成为临床靶向肿瘤组织、协同免疫机制杀死肿瘤细胞、治疗肿瘤的有效载体基础和治疗手段。本文综述了近年来应用于化疗和各种免疫治疗的多功能纳米药物的种类及其在癌症治疗中的优势。关键词:纳米医学;癌症治疗;免疫治疗;化疗;联合治疗
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