Neutrophil Lymphocyte Ratio and Red Cell Distribution Width as a Marker of Preeclampsia: A Retrospective Study

Journal of pregnancy and child health Pub Date : 2017-03-19 DOI:10.4172/2376-127X.1000307

Damar Prasmusinto, Rosalyn C Jono, Yuyun Lisnawati

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引用次数: 8

Abstract

Background: Preeclampsia occurs in 3-7% of pregnancy and contributes to 18% maternal mortality. Unfortunately, proper diagnosis and prompt treatment for preeclampsia are lim ited in rural area due to limited facilities. Neutrophils, lymphocytes, and red distribution width, some of the inflammatory response, are considered as marker for preeclampsia. We evaluated the NTR and RDW as a reliable marker for preeclampsia in limited facilities health care. Methods: A retrospective study was conducted to 254 pregnancies at Persahabatan Hospital, Jakarta, Indonesia. We obtained NTR and RDW data from the complete blood count panels and differed to two groups: pregnancies with preeclampsia and not, early and late onset of preeclampsia. We analyzed with T-test and Mann- Whitney test using SPSS 20.0 and performed diagnostic analysis in investigating sensitivity and specificity of NTR and RDW as marker tools. Results: There were 136 pregnancies with preeclampsia and 118 normal pregnancies. Pregnancies with preeclampsia showed higher NTR with mean 4.41 (95% CI 1.41-32.54, p<0.001) and RDW with median 14.2 (95% CI 1.48-23.90, p<0.001). Onset of preeclampsia did not influence the NTR with median of early onset preeclampsia 4.35 (95%CI 1.41-17.56) and late onset of preeclampsia 4.41 (95% CI 1.69-32.54). Hence, RDW showed statistically significance (power 97.29%, p<0.001) as higher range was obtained in the late onset of preeclampsia (95% CI 14.91 ± 2.16) that in the early onset of preeclampsia (95% CI 13.50 ± 1.47). In ROC (Receiver Operating Characteristic) curve analysis, NTR become an important marker for preeclampsia with sensitivity 80.1% and specificity 87.3% (95%CI 0.85-0.93, cut off value 3.295). RDW shows sensitivity 50.7% and specificity 71.2% (95%CI 0.55-0.69, cut off value 14.17). Conclusion: NTR and RDW can be markers for preeclampsia as higher NTR and RDW, as inflammatory responses, may be related to preeclampsia.

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中性粒细胞淋巴细胞比率和红细胞分布宽度作为子痫前期的标志物:回顾性研究

背景:先兆子痫发生在3-7%的妊娠，导致18%的产妇死亡率。不幸的是，由于农村地区设施有限，对子痫前期的正确诊断和及时治疗是有限的。中性粒细胞、淋巴细胞和红色分布宽度等炎症反应被认为是子痫前期的标志。我们评估了NTR和RDW作为有限设施医疗机构中先兆子痫的可靠标志物。方法:对印度尼西亚雅加达Persahabatan医院的254例孕妇进行回顾性研究。我们从全血细胞计数面板中获得NTR和RDW数据，并在两组中有所不同:先兆子痫和非先兆子痫，早发和晚发子痫。采用SPSS 20.0软件进行t检验和Mann- Whitney检验，并对NTR和RDW作为标志物的敏感性和特异性进行诊断分析。结果:子痫前期妊娠136例，正常妊娠118例。先兆子痫妊娠的NTR平均值为4.41 (95% CI 1.41-32.54, p<0.001)， RDW平均值为14.2 (95% CI 1.48-23.90, p<0.001)。先兆子痫的发病不影响NTR，早发型子痫前期的中位值为4.35 (95%CI 1.41 ~ 17.56)，晚发型子痫前期的中位值为4.41 (95%CI 1.69 ~ 32.54)。因此，RDW在晚发型子痫前期(95% CI 14.91±2.16)高于早发型子痫前期(95% CI 13.50±1.47)，具有统计学意义(功率97.29%，p<0.001)。在ROC (Receiver Operating Characteristic)曲线分析中，NTR以80.1%的敏感性和87.3%的特异性(95%CI 0.85 ~ 0.93，截断值3.295)成为子痫前期的重要标志物。RDW敏感性50.7%，特异性71.2% (95%CI 0.55 ~ 0.69，截断值14.17)。结论:NTR和RDW可作为子痫前期的标志物，NTR和RDW作为炎症反应可能与子痫前期有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of pregnancy and child health

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