Advanced glycation end products and allergy

Q3 Medicine

Allergo Journal International Pub Date : 2023-06-28 DOI:10.1007/s40629-023-00259-4

Masako Toda, Michael Hellwig, Hiroyuki Hattori, Thomas Henle, Stefan Vieths

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Abstract

This review aims to summarize our current knowledge of the impact of advanced glycation products (AGEs) in the diet on the development of allergies. The association between modern dietary patterns that contain high amounts of thermally processed food products, and the development of allergies is of great concern. One group of molecules generated by such dietary patterns is AGEs resulting from the Maillard reaction (MR). Evidence suggests that the MR could influence the allergenicity of food proteins because it alters the structure of proteins by modifying lysine and arginine residues with various types of AGE structures. Several studies, including ours, have indicated that certain AGEs affect innate immune responses via the engagement of AGE-binding receptors. AGEs could also influence the composition of the gut microbiome and its metabolites. Collectively, AGEs may alter the risk of multiple disorders, including allergies, by interacting with innate immunity and changing the gut microbiome.

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晚期糖基化终产物与过敏

这篇综述旨在总结我们目前对饮食中晚期糖基化产物（AGEs）对过敏发展的影响的认识。含有大量热加工食品的现代饮食模式与过敏的发展之间的联系备受关注。这种饮食模式产生的一组分子是美拉德反应（MR）产生的AGEs。有证据表明，MR可能会影响食物蛋白质的致敏性，因为它通过用各种类型的AGE结构修饰赖氨酸和精氨酸残基来改变蛋白质的结构。包括我们在内的几项研究表明，某些AGE通过与AGE结合受体的结合来影响先天免疫反应。AGEs也可能影响肠道微生物组及其代谢产物的组成。总之，AGEs可以通过与先天免疫相互作用和改变肠道微生物组来改变包括过敏在内的多种疾病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergo Journal International Medicine-Immunology and Allergy

CiteScore

4.60

自引率

0.00%

发文量

期刊介绍： Allergo Journal International is the official Journal of the German Society for Applied Allergology (AeDA) and the Austrian Society for Allergology and Immunology (ÖGAI). The journal is a forum for the communication and exchange of ideas concerning the various aspects of allergy (including related fields such as clinical immunology and environmental medicine) and promotes German allergy research in an international context. The aim of Allergo Journal International is to provide state of the art information for all medical and scientific disciplines that deal with allergic, immunological and environmental diseases. Allergo Journal International publishes original articles, reviews, short communications, case reports, and letters to the editor. The articles cover topics such as allergic, immunological and environmental diseases, the latest developments in diagnosis and therapy as well as current research work concerning antigens and allergens and aspects related to occupational and environmental medicine. In addition, it publishes clinical guidelines and position papers approved by expert panels of the German, Austrian and Swiss Allergy Societies. All submissions are reviewed in single-blind fashion by at least two reviewers. Originally, the journal started as a German journal called Allergo Journal back in 1992. Throughout the years, English articles amounted to a considerable portion in Allergo Journal. This was one of the reasons to extract the scientific content and publish it in a separate journal. Hence, Allergo Journal International was born and now is the international continuation of the original German journal. Nowadays, all original content is published in Allergo Journal International first. Later, selected manuscripts will be translated and published in German and included in Allergo Journal.