Synergistic Effects of Nano-Sized Clinoptilolite and Nigella Sativa on Inflammatory and Hematological Factors in Rats with Type 2 Diabetes

Journal of molecular biology research Pub Date : 2019-01-21 DOI:10.5539/JMBR.V9N1P7

Elahe Bazri, S. Khorram, M. Mesgari, M. Asghari-Jafarabadi, A. Tarighat-Esfanjani, Yalda Salari

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Abstract

The inflammatory efficacy of supplementation of natural nano-sized clinoptilolite (NCLN) and Nigella sativa (NS) was evaluated At the end of 7th week in interleukin1β (IL1β), interleukin10 (IL-10), interleukin6 (IL-6) and platelet (PLT), white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV). 42 rats were divided into two groups as diabetic and non-diabetic. Diabetic group divided into 4 subgroups as normal control (NC), NS 1% food, NCLN 2%/food, NS 1%/food + NCLN 2%/food and fed high fat diet (HFD) for 1 month, then injected 35mg/kg BW STZ to induce type 2 diabetes (T2D). Our results showed IL-10 in NCLN and NCLN+NS groups were significantly higher NC group (p<0.05). IL-6 decreased in NS group in comparison with DC group. And PLT decreased significantly in NCLN group in comparison with other groups. Our data suggests NS and NCLN may have synergistic beneficial effects on increasing some of anti-inflammatory factors.

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纳米斜发沸石和Nigella Sativa对2型糖尿病大鼠炎症和血液学因子的协同作用

在第7周结束时，观察添加天然纳米斜发石(NCLN)和黑鬼(NS)的抗炎效果，包括白细胞介素1β (il -1 β)、白细胞介素10 (IL-10)、白细胞介素6 (IL-6)和血小板(PLT)、白细胞(WBC)、红细胞(RBC)、血红蛋白(HGB)、红细胞压积(HCT)、平均红细胞血红蛋白(MCH)、平均红细胞血红蛋白浓度(MCHC)、平均红细胞体积(MCV)。将42只大鼠分为糖尿病组和非糖尿病组。糖尿病组分为正常对照组(NC)、NS 1%食物组、NCLN 2%/食物组、NS 1%/食物组+ NCLN 2%/食物组4个亚组，分别饲喂高脂饲料(HFD) 1个月，然后注射STZ 35mg/kg BW诱导2型糖尿病(T2D)。结果显示，NCLN组和NCLN+NS组IL-10显著高于NC组(p<0.05)。与DC组比较，NS组IL-6明显降低。与其他各组相比，NCLN组PLT明显降低。我们的数据表明，NS和NCLN可能在增加某些抗炎因子方面具有协同有益作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of molecular biology research

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