Tranexamic Acid and the Risk of Delirium after Off-Pump Surgery.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2022-06-06 DOI:10.1055/s-0042-1745811

Nikolai Hulde, Armin Zittermann, Marcus-Andre Deutsch, Jan F Gummert, Vera von Dossow, Andreas Koster

引用次数: 0

Abstract

We investigated whether in patients undergoing off-pump coronary artery bypass grafting surgery a single bolus of 1 g tranexamic acid (TXA) impacts the risk of postoperative delirium using the propensity score matching approach. In 2,757 pairs, the risk of delirium was 4.2% (TXA group) and 5.0% (non-TXA group), with a relative risk in the TXA versus the non-TXA group of 0.83 (95% confidence interval: 0.65-1.07; p = 0.16). There was no significant interaction between TXA administration and renal function on the risk of delirium (p = 0.12). Data indicate that a single bolus of 1 g TXA does not increase the risk of delirium in patients undergoing off-pump surgery.

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氨甲环酸与非泵手术后谵妄的风险。

我们使用倾向评分匹配方法研究了非体外循环冠状动脉搭桥术患者单次注射1g氨甲环酸(TXA)是否会影响术后谵妄的风险。在2757对患者中，患谵妄的风险分别为4.2% (TXA组)和5.0%(非TXA组)，TXA组与非TXA组的相对风险为0.83(95%可信区间:0.65-1.07;p = 0.16)。TXA给药与肾功能对谵妄风险无显著相互作用(p = 0.12)。数据表明，单次1克TXA不会增加非泵手术患者谵妄的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.