New halimane and clerodane diterpenoids from Croton cnidophyllus

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL

Natural Products and Bioprospecting Pub Date : 2023-07-06 DOI:10.1007/s13659-023-00386-z

Xun Wei, Jia-Luo Huang, Hua-Hua Gao, Fang-Yu Yuan, Gui-Hua Tang, Sheng Yin

{"title":"New halimane and clerodane diterpenoids from Croton cnidophyllus","authors":"Xun Wei, Jia-Luo Huang, Hua-Hua Gao, Fang-Yu Yuan, Gui-Hua Tang, Sheng Yin","doi":"10.1007/s13659-023-00386-z","DOIUrl":null,"url":null,"abstract":"<div><p>Three new halimane furanoditerpenoids (<b>1</b>–<b>3</b>) and three new clerodane furanoditerpenoids (<b>4</b>–<b>6</b>), along with seven known terpenoids including four pimarane diterpenoids (<b>7</b>–<b>10</b>) and three norisoprenoids (<b>11</b>–<b>13</b>) were isolated from the 95% EtOH extracts of the plants of <i>Croton cnidophyllus</i>. The 2D structures including absolute configuration of new furanoditerpenoids (<b>1</b>–<b>6</b>) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (<b>8</b> and <b>9</b>) possessed certain inhibitory effects against NO production stimulated by LPS, with IC<sub>50</sub> values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively.</p><h3>Graphical Abstract</h3>\n <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\n </div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-023-00386-z.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Products and Bioprospecting","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13659-023-00386-z","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

Three new halimane furanoditerpenoids (1–3) and three new clerodane furanoditerpenoids (4–6), along with seven known terpenoids including four pimarane diterpenoids (7–10) and three norisoprenoids (11–13) were isolated from the 95% EtOH extracts of the plants of Croton cnidophyllus. The 2D structures including absolute configuration of new furanoditerpenoids (1–6) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (8 and 9) possessed certain inhibitory effects against NO production stimulated by LPS, with IC₅₀ values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively.

Graphical Abstract

Abstract Image

查看原文本刊更多论文

巴豆刺叶属新盐烷和氯烷二萜

从巴豆95% EtOH提取物中分离得到3个新的卤烷类呋喃二萜(1-3)和3个新的氯烷类呋喃二萜(4-6)，以及4个已知的海玛烷类二萜(7-10)和3个异戊二萜(11-13)。通过对新呋喃二萜(1-6)的HRMS和NMR数据的分析，以及实验和计算ECD曲线的比较，确定了它们的二维结构，包括绝对构型。生物实验结果表明，化合物8和9对LPS刺激NO生成具有一定的抑制作用，IC50值分别为19.00±1.76 μM和21.61±1.11 μM。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.