Sammy A. Ojo , Dare Victor Abere , Helen Ojoma Adejo , Rosanna Ann Robert , Kunle Michael Oluwasegun
{"title":"Additive manufacturing of hydroxyapatite-based composites for bioengineering applications","authors":"Sammy A. Ojo , Dare Victor Abere , Helen Ojoma Adejo , Rosanna Ann Robert , Kunle Michael Oluwasegun","doi":"10.1016/j.bprint.2023.e00278","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span><span>Hydroxyapatite (HA) is a promising support structure for </span>tissue engineering that has considerably gained a lot of interest in recent years due to its potential applications in the </span>biomedical industry<span> and biocompatibility characteristics to make easier proliferation and cellular growth tissue </span></span>implants<span> in patient<span><span><span>. Different materials, notably heterogeneous biomaterials characterized as matrix material<span> and strengthening materials have recently been suggested as materials that can be utilized to produce scaffolds<span> with better bioactive features. Depending on the chemical resemblance of HA with inorganic cultural and biological mineralized structures, considerable innovations have been devoted to hydroxyapatite (HA)-reinforced materials, mainly focusing on bone tissue development. To produce artificial porous bone in structure is challenging with conventional processes. </span></span></span>Additive manufacturing<span> (AM) offers a precise, reproductive, and accurate approach to fabricating complex and functional geometry of biomedical materials such as internal microporous structures in a layer-by-layer fashion from three-dimensional models. The present review identified the recent development of AM methods in producing HA-reinforced composite and </span></span>biocomposites materials such as cellular components. It highlighted and reviewed different AM technologies used in the fabrication of HA and its composite materials and </span></span></span>mechanical properties of HA scaffold produced by AM. The reviewed study present a comprehensive overview of the discussed technologies and suggestions for future perspectives to provide a comprehensive view of the techniques explored and complexities in this evolving field.</p></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioprinting","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405886623000210","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}
引用次数: 3
Abstract
Hydroxyapatite (HA) is a promising support structure for tissue engineering that has considerably gained a lot of interest in recent years due to its potential applications in the biomedical industry and biocompatibility characteristics to make easier proliferation and cellular growth tissue implants in patient. Different materials, notably heterogeneous biomaterials characterized as matrix material and strengthening materials have recently been suggested as materials that can be utilized to produce scaffolds with better bioactive features. Depending on the chemical resemblance of HA with inorganic cultural and biological mineralized structures, considerable innovations have been devoted to hydroxyapatite (HA)-reinforced materials, mainly focusing on bone tissue development. To produce artificial porous bone in structure is challenging with conventional processes. Additive manufacturing (AM) offers a precise, reproductive, and accurate approach to fabricating complex and functional geometry of biomedical materials such as internal microporous structures in a layer-by-layer fashion from three-dimensional models. The present review identified the recent development of AM methods in producing HA-reinforced composite and biocomposites materials such as cellular components. It highlighted and reviewed different AM technologies used in the fabrication of HA and its composite materials and mechanical properties of HA scaffold produced by AM. The reviewed study present a comprehensive overview of the discussed technologies and suggestions for future perspectives to provide a comprehensive view of the techniques explored and complexities in this evolving field.
期刊介绍:
Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.