Prognosis and Outcome of Cerebral Sinus Venous Thrombosis—A Multicenter Cohort Study

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Acta Neurologica Scandinavica Pub Date : 2023-02-07 DOI:10.1155/2023/8016006

N. Simaan, A. Honig, H. Hallevi, E. Seyman, O. Rotschild, E. Assayag, A. Filioglo, S. Peretz, R. Mendel, R. Barnea, E. Auriel, S. Aladdin, D. Orion, Khalil Darawsha, Fadi Shbat, R. Leker, J. Molad

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Abstract

Objectives. Cerebral sinus venous thrombosis (CSVT) is a rare stroke subtype and data regarding prognostic factors to predict outcomes are lacking. Thus, we aimed to identify predictors for outcome among CSVT patients. Materials and Methods. Prospective CSVT databases from four academic medical centers were retrospectively studied. Demographics, clinical presentations, risk factors, radiological, and outcome parameters were compared. Results. Out of 508 patients diagnosed with CSVT, 21 patients (4%) died, and 91 (18.6%) had unfavorable outcome ( mRS ≥ 2 ). Age (55.0 vs. 38.5, p < 0.001 ), hypertension (26% vs. 6%, p < 0.001 ), hyperlipidemia (23% vs. 6%, p < 0.001 ), diabetes (17% vs. 4%, p < 0.001 ), malignancy (35% vs. 11%, p < 0.001 ), absence of headache (51% vs. 78%, p < 0.001 ), focal neurological deficit (54% vs. 19%, p < 0.001 ), and ICH (28% vs. 13%, p < 0.001 ) were all associated with unfavorable outcome. After multivariate analysis malignancy (OR 4.2, p = 0.003 ), the presence of focal neurological deficit (OR 5.2, p < 0.001 ) and the presence of headache upon presentation (OR 0.334, p = 0.018 ) remained significant predictors for favorable outcome. Conclusions. Among CSVT patients, malignancy, focal neurological deficits, and absence of headache at presentation were associated with unfavorable outcomes.

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脑窦静脉血栓形成的预后和结局——一项多中心队列研究

目标。脑窦静脉血栓形成(CSVT)是一种罕见的卒中亚型，缺乏预测预后的预后因素数据。因此，我们旨在确定CSVT患者预后的预测因素。材料与方法。回顾性研究了来自四个学术医学中心的前瞻性CSVT数据库。比较了人口统计学、临床表现、危险因素、放射学和结局参数。结果。508例诊断为CSVT的患者中，21例(4%)死亡，91例(18.6%)出现不良结局(mRS≥2)。年龄(55.0比38.5,p < 0.001)、高血压(26%比6%，p < 0.001)、高脂血症(23%比6%，p < 0.001)、糖尿病(17%比4%，p < 0.001)、恶性肿瘤(35%比11%，p < 0.001)、无头痛(51%比78%，p < 0.001)、局灶性神经功能缺损(54%比19%，p < 0.001)和脑出血(28%比13%，p < 0.001)均与不良结局相关。多变量分析后，恶性肿瘤(OR 4.2, p = 0.003)、局灶性神经功能缺损(OR 5.2, p < 0.001)和就诊时出现头痛(OR 0.334, p = 0.018)仍然是预后良好的重要预测因素。结论。在CSVT患者中，恶性肿瘤、局灶性神经功能缺损和就诊时无头痛与不良预后相关。

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来源期刊

Acta Neurologica Scandinavica 医学-临床神经学

CiteScore

6.70

自引率

2.90%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Acta Neurologica Scandinavica aims to publish manuscripts of a high scientific quality representing original clinical, diagnostic or experimental work in neuroscience. The journal''s scope is to act as an international forum for the dissemination of information advancing the science or practice of this subject area. Papers in English will be welcomed, especially those which bring new knowledge and observations from the application of therapies or techniques in the combating of a broad spectrum of neurological disease and neurodegenerative disorders. Relevant articles on the basic neurosciences will be published where they extend present understanding of such disorders. Priority will be given to review of topical subjects. Papers requiring rapid publication because of their significance and timeliness will be included as ''Clinical commentaries'' not exceeding two printed pages, as will ''Clinical commentaries'' of sufficient general interest. Debate within the speciality is encouraged in the form of ''Letters to the editor''. All submitted manuscripts falling within the overall scope of the journal will be assessed by suitably qualified referees.