Harmine and its derivatives: Biological activities and therapeutic potential in human diseases

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2018-07-07 DOI:10.3329/BJP.V13I3.34990

M. Javeed, A. Rasul, G. Hussain, F. Jabeen, Bilal Rasool, Ammara Riaz, G. Kaukab, Muhammad Ishtiaq Ali

引用次数: 7

Abstract

This review article aims to provide an update on the sources, pharmaco-logical and biological profile of a β-carboline alkaloid, harmine which is a major bioactive component of various plants mainly Peganum harmala. Harmine’s wide range of pharmacological properties has been well-documented as anti-cancer, anti-inflammatory, anti-oxidant, neuroprotective, anti-depressant, and antimicrobial. Although reported data suggests a multifunctional pharmacological role of harmine but farther experimentation on its molecular mechanism of action, synthetic chemistry approaches, and preclinical studies are yet obligatory to fully uncover its pharmacological efficacy.

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毒碱及其衍生物:在人类疾病中的生物活性和治疗潜力

本文主要介绍了一种β-碳碱生物碱——毒碱的来源、药理和生物学研究进展。毒碱是多种植物中主要的生物活性成分。鼠碱广泛的药理特性已被充分证明为抗癌、抗炎、抗氧化、神经保护、抗抑郁和抗菌。虽然报道的数据表明，毒草碱具有多种药理作用，但要充分揭示其药理作用，还需要进一步的分子作用机制实验、合成化学方法和临床前研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.