Altered Auditory P300 Performance in Parents with Attention Deficit Hyperactivity Disorder Offspring

IF 2.4 4区医学 Q3 NEUROSCIENCES

Clinical Psychopharmacology and Neuroscience Pub Date : 2019-11-01 DOI:10.9758/cpn.2019.17.4.509

M. Chi, C. Chu, I. Lee, Y. Hsieh, Ko Chin Chen, P. Chen, Yen Kuang Yang

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引用次数: 7

Abstract

Objective Altered event-related potential (ERP) performances have been noted in attention deficit hyperactivity disorder (ADHD) patients and reflect neurocognitive dysfunction. Whether these ERP alterations and correlated dysfunctions exist in healthy parents with ADHD offspring is worth exploring. Methods Thirteen healthy parents with ADHD offspring and thirteen healthy controls matched for age, sex and years of education were recruited. The auditory oddball paradigm was used to evaluate the P300 wave complex of the ERP, and the Wechsler Adult Intelligence Scale-Revised, Wisconsin Card Sorting Test, and continuous performance test were used to measure neurocognitive performance. Results Healthy parents with ADHD offspring had significantly longer auditory P300 latency at Fz than control group. However, no significant differences were found in cognitive performance. Conclusion The presence of a subtle alteration in electro-neurophysiological activity without explicit neurocognitive dysfunction suggests potential candidate of biological marker for parents with ADHD offspring.

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注意缺陷多动障碍父母后代听觉P300表现的改变

目的注意缺陷多动障碍(ADHD)患者事件相关电位(ERP)表现的改变反映了神经认知功能障碍。这些ERP改变和相关功能障碍是否存在于有ADHD后代的健康父母中值得探讨。方法招募13名有ADHD子女的健康父母和13名年龄、性别、受教育年限相匹配的健康对照。采用听觉古怪范式评估ERP的P300波复合体，采用韦氏成人智力量表、威斯康星卡片分类测验和连续表现测验评估神经认知能力。结果ADHD患儿健康父母在Fz时听觉P300潜伏期明显长于对照组。然而，在认知表现方面没有发现显著差异。结论无明显神经认知功能障碍的电神经生理活动的细微改变提示了ADHD后代父母的潜在生物学标记物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Psychopharmacology and Neuroscience NEUROSCIENCESPHARMACOLOGY & PHARMACY-PHARMACOLOGY & PHARMACY

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： Clinical Psychopharmacology and Neuroscience (Clin Psychopharmacol Neurosci) launched in 2003, is the official journal of The Korean College of Neuropsychopharmacology (KCNP), and the associate journal for Asian College of Neuropsychopharmacology (AsCNP). This journal aims to publish evidence-based, scientifically written articles related to clinical and preclinical studies in the field of psychopharmacology and neuroscience. This journal intends to foster and encourage communications between psychiatrist, neuroscientist and all related experts in Asia as well as worldwide. It is published four times a year at the last day of February, May, August, and November.