Convergence and divergence in the metabolic network of Mycobacterium tuberculosis

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Systems Biology Pub Date : 2021-12-01 DOI:10.1016/j.coisb.2021.100384

Catherine B. Hubert, Luiz Pedro S. de Carvalho

引用次数: 3

Abstract

Metabolism is still often regarded as a set of canonical reactions, identical in all organisms, yet that is far from correct. Metabolism and the metabolic networks required for cellular functions vary dramatically even within species. This diversity is also present in bacterial pathogens. This mini-review explores the role of metabolic convergence and divergence in shaping the metabolic network of Mycobacterium tuberculosis and its ability to survive in the host. With the help of a few selected examples, we aim to illustrate the magnitude of changes observed in M. tuberculosis metabolic network.

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结核分枝杆菌代谢网络的趋同与分化

新陈代谢仍然经常被认为是一系列规范的反应，在所有生物体中都是一样的，但这远远不正确。新陈代谢和细胞功能所需的代谢网络即使在物种内也有很大差异。这种多样性也存在于细菌病原体中。这篇小型综述探讨了代谢趋同和分化在塑造结核分枝杆菌代谢网络及其在宿主中生存能力中的作用。在一些选定的例子的帮助下，我们的目的是说明结核分枝杆菌代谢网络中观察到的变化幅度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Systems Biology Mathematics-Applied Mathematics

CiteScore

7.10

自引率

2.70%

发文量

期刊介绍： Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution

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