Development and characterization of niosomal gel of fusidic acid: in-vitro and ex-vivo approaches

IF 1.8 4区化学 Q3 POLYMER SCIENCE

Designed Monomers and Polymers Pub Date : 2022-06-09 DOI:10.1080/15685551.2022.2086411

M. Waqas, H. Sadia, Muhammad Imran Khan, M. Omer, M. Siddique, Shaista Qamar, Muhammad Zaman, M. H. Butt, M. W. Mustafa, Naeem Rasool

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引用次数: 15

Abstract

ABSTRACT Niosomes are multilamellar vesicles that efficiently deliver active substance into skin systemic circulation or skin layers. They are used in topical drug delivery system to enhance the skin permeation of active substance. So, the prime objective of this study was to develop a niosomal gel of fusidic acid to increase its skin permeation. Different formulations of niosomes of fusidic acid were designed by varying the cholesterol to surfactant ratio. Formulations containing fusidic acid, cholesterol, dihexadecyl pyridinium chloride, Span 60, or Tween 60 were prepared by thin film hydration method in rotary evaporator. The thin film formed in rotary flask was hydrated by phosphate buffer saline of pH 7.2. The niosomes formed were characterized through entrapment efficiency, size, polydispersity index (PDI), and zeta potential. The S3 formulation containing span 60 showed the highest entrapment efficiency (EE) of niosomes, so it was incorporated into Carbopol gel. Determination of pH, spreadability, rheological, and ex vivo permeation studies was conducted of niosomal gel. The results of ex vivo permeation studies showed high permeation of fusidic acid when gel was applied to an albino rat skin. According to the results and previous studies of niosomes, it can be concluded that niosomes enhanced the permeation of fusidic acid through the skin.

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梭氨酸脂质体凝胶的制备与表征：体外和离体方法

乳小体是一种多层囊泡，能有效地将活性物质输送到皮肤体循环或皮肤层中。它们用于局部给药系统，以增强活性物质的皮肤渗透。因此，本研究的主要目的是开发一种福西地酸乳质体凝胶，以增加其皮肤渗透。通过改变胆固醇与表面活性剂的比例，设计了不同的夫西地酸乳质体配方。采用薄膜水化法在旋转蒸发器中制备了含氟西地酸、胆固醇、二十六基氯化吡啶、Span 60和Tween 60的配方。在旋转烧瓶中形成的薄膜用pH为7.2的磷酸盐缓冲盐水水化。通过包裹效率、大小、多分散性指数(PDI)和zeta电位对所形成的纳米体进行表征。含span 60的S3配方对纳米体的包封效率(EE)最高，因此将其掺入Carbopol凝胶中。测定了乳质体凝胶的pH值、涂抹性、流变学和体外渗透研究。体外渗透研究结果表明，将凝胶应用于白化大鼠皮肤时，富西地酸具有较高的渗透性。根据研究结果和以往对乳质体的研究，可以得出乳质体可以增强夫西地酸通过皮肤的渗透。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Designed Monomers and Polymers 化学-高分子科学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

2.1 months

期刊介绍： Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications