The Molecular Diversity of 1H-Indole-3-Carbaldehyde Derivatives and Their Role in Multicomponent Reactions

IF 8.6 2区化学 Q1 Chemistry

Topics in Current Chemistry Pub Date : 2022-04-25 DOI:10.1007/s41061-022-00379-5

Ghodsi Mohammadi Ziarani, Samira Hasani, Fatemeh Mohajer, Rajender S. Varma, Fatemeh Rafiee

引用次数: 1

Abstract

1H-Indole-3-carbaldehyde and related members of the indole family are ideal precursors for the synthesis of active molecules. 1H-Indole-3-carbaldehyde and its derivatives are essential and efficient chemical precursors for generating biologically active structures. Multicomponent reactions (MCRs) offer access to complex molecules. This review highlights the recent applications of 1H-indole-3-carbaldehyde in such inherently sustainable multicomponent reactions from the period, 2014 to 2021 and provides an overview of the field that awaits further exploitation in the assembly of pharmaceutically interesting scaffolds.

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1H-吲哚-3-甲醛衍生物的分子多样性及其在多组分反应中的作用

1h -吲哚-3-乙醛和吲哚家族的相关成员是合成活性分子的理想前体。1h -吲哚-3-乙醛及其衍生物是生成生物活性结构必不可少的高效化学前体。多组分反应(mcr)提供了获取复杂分子的途径。本文重点介绍了2014年至2021年期间1h -吲哚-3-乙醛在这种内在可持续的多组分反应中的最新应用，并概述了该领域在药学上有趣的支架组装方面的进一步开发。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.