Interactions between Bisphenol S or Dibutyl Phthalates and Reproductive System

Abstract

Endocrine disrupting chemicals (EDCs) adversely affect animals and human beings. This attracted the researchers in the previous decade to explore the possible associa tion of these chemicals. However, among various studies, very limited data is available to explain the link between EDCs and reproductive tract outcome. One reason is that many potential EDCs and their probable mechanisms and underlying causes have not been studied so far. Bisphenol S (BPS) is used as an alternative of bisphenol A, after the worse effects of this bisphenol. Similarly, dibutyl phthalate (DBP) is the least studied of its group. Dibutyl phthalate is widely used in polyvinyl plastic products. The current chapter aims to explore the possibly association of these two chemicals with animals and humans. it is concluded that the increase use of plastic products enhances the phthalates in environment. The epidemiological studies of human as well experimental trials on animal models investigated the adverse effect of BPS and DBP at lower and higher doses. The reproductive system of male and female are at higher risk of exposure to these chemicals. In females, reduced size of mammary glands, degenera tion of ovaries, immature follicles, and pubertal disorders were observed. While in males, decrease in sperm count, damage to sperm duct, and reduced testis was examined in vari ous animal models.