Unveiling the Lack of Inotropic Response of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Isoproterenol by Chronic External Stimulation

Q2 Health Professions

Applied In Vitro Toxicology Pub Date : 2020-06-01 DOI:10.1089/aivt.2020.0002

Haoyu Zeng, Jixin Wang, Holly Clouse, A. Lagrutta

引用次数: 0

Abstract

Introduction: The lack of positive inotropic response to isoproterenol has been a caveat in the utilization of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for cardiac saf...

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揭示人诱导的多能干细胞来源的心肌细胞在慢性外部刺激下对异丙肾上腺素缺乏肌力反应

引言：缺乏对异丙肾上腺素的正性肌力反应是利用人类诱导多能干细胞衍生的心肌细胞（hiPSC CMs）进行心脏安全的一个警告。。。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied In Vitro Toxicology Health Professions-Medical Laboratory Technology

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Applied In Vitro Toxicology is a peer-reviewed journal providing the latest research on the application of alternative in vitro testing methods for predicting adverse effects in the pharmaceutical, chemical, and personal care industries. This Journal aims to address important issues facing the various chemical industries, including regulatory requirements; the reduction, refinement, and replacement of animal testing; new screening methods; evaluation of new cell and tissue models; and the most appropriate methods for assessing safety and satisfying regulatory demands. The Journal also delivers the latest views and opinions of developers of new models, end users of the models, academic laboratories that are inventing new tools, and regulatory agencies in the United States, Europe, Latin America, Australia and Asia. Applied In Vitro Toxicology is the journal that scientists involved with hazard identification and risk assessment will read to understand how new and existing in vitro methods are applied, and the questions for which these models provide answers. Applied In Vitro Toxicology coverage includes: -Applied in vitro toxicology industry standards -New technologies developed for applied in vitro toxicology -Data acquisition, cleaning, distribution, and best practices -Data protection, privacy, and policy -Business interests from research to product -The changing role of in vitro toxicology -Visualization and design principles of applied in vitro toxicology infrastructures -Physical interfaces and robotics -Opportunities around applied in vitro toxicology