Potency of Cape Gooseberry (Physalis Peruviana) Juice in Improving Antioxidant and Adiponectin Level of High Fat Diet Streptozotocin Rat Model

Q4 Medicine
Luthfia Dewi, M. Sulchan, Kisdjamiatun
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引用次数: 6

Abstract

Abstract Background and aims: Quercetin belonging flavonoid has a role to improve diabetic condition. Research aimed to examine and to compare Cape Gooseberry (CG) juice and quercetin supplement on Total Antioxidant Capacity (TAC) and adiponectin level of high fat diet-Streptozotocin (HFD-STZ) induced rat. Material and method: CG juice 5 ml/kg/d (X1) and 25 ml/kg/d (X2) groups; and quercetin supplement 2.2 mg/kg/d (X3) and 30 mg/kg/d (X4) groups were compared with both of positive (K+) and negative (K-) control. Treatments were given by orally gavage for 28 days to 36 Wistar rats which each group consisted of 6 rats. TAC and adiponectin level were measured by ABTS and ELISA method respectively. Results: There was significantly increase of TAC in treatment groups compared with K(+) (p<0.05). X2 had TAC level significantly higher than X1 (p=0.025). Moreover, adiponectin level of treatment groups were significantly higher than K(+) (p<0.05). Furthermore, X2 had adiponectin level significantly higher than X3 (p<0.001). Conclusion: CG juice 25 ml/kg/d presented better effect than CG juice 5 ml/kg/d, although quercetin 30 mg/kg/d showed the best effects toward both of TAC and adiponectin.
猕猴桃汁提高高脂饲粮链脲佐菌素模型大鼠抗氧化和脂联素水平的作用
摘要背景与目的:槲皮素类黄酮具有改善糖尿病的作用。研究了枸杞(CG)汁和槲皮素对高脂饮食-链脲佐菌素(HFD-STZ)诱导大鼠总抗氧化能力(TAC)和脂联素水平的影响。材料和方法:CG果汁5 ml/kg/d (X1)组和25 ml/kg/d (X2)组;槲皮素添加2.2 mg/kg/d (X3)和30 mg/kg/d (X4)组均为阳性(K+)对照和阴性(K-)对照。Wistar大鼠36只,每组6只,灌胃治疗28 d。采用ABTS法和ELISA法分别测定TAC和脂联素水平。结果:各治疗组TAC与K(+)组比较,差异有统计学意义(p<0.05)。X2组TAC水平显著高于X1组(p=0.025)。治疗组脂联素水平显著高于K(+)组(p<0.05)。X2组脂联素水平显著高于X3组(p<0.001)。结论:CG汁25 ml/kg/d的效果优于CG汁5 ml/kg/d,槲皮素30 mg/kg/d对TAC和脂联素的效果最好。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
49
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