Viscoelastic properties of normal rat liver measured by ultrasound elastography: Comparison with oscillatory rheometry.

IF 1 4区医学 Q4 BIOPHYSICS

Biorheology Pub Date : 2017-03-29 DOI:10.3233/BIR-16091

Haoming Lin, Yuanyuan Shen, Xin Chen, Ying Zhu, Yi Zheng, Xinyu Zhang, Yanrong Guo, Tianfu Wang, Siping Chen

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引用次数: 5

Abstract

BACKGROUND Ultrasound elastography has been widely used to measure liver stiffness. However, the accuracy of liver viscoelasticity obtained by ultrasound elastography has not been well established. OBJECTIVE To assess the accuracy of ultrasound elastography for measuring liver viscoelasticity and compare to conventional rheometry methods. In addition, to determine if combining these two methods could delineate the rheological behavior of liver over a wide range of frequencies. METHODS The phase velocities of shear waves were measured in livers over a frequency range from 100 to 400 Hz using the ultrasound elastography method of shearwave dispersion ultrasound vibrometry (SDUV), while the complex shear moduli were obtained by rheometry over a frequency range of 1 to 30 Hz. Three rheological models, Maxwell, Voigt, and Zener, were fit to the measured data obtained from the two separate methods and from the combination of the two methods. RESULTS The elasticity measured by SDUV was in good agreement with that of rheometry. However, the viscosity measured by SDUV was significantly different from that of rheometry. CONCLUSIONS The results indicate that the high frequency components of the dispersive data play a much more important role in determining the dispersive pattern or the viscous value than the low frequency components. It was found that the Maxwell model is not as appropriate as the Voigt and Zener models for describing the rheological behavior of liver.

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超声弹性成像测量正常大鼠肝脏的粘弹性特性:与振荡流变仪的比较。

背景超声弹性成像已被广泛用于测量肝脏硬度。然而，通过超声弹性成像获得的肝脏粘弹性的准确性尚未得到很好的证实。目的评估超声弹性成像测量肝脏粘弹性的准确性，并与传统的流变仪方法进行比较。此外，为了确定将这两种方法结合起来是否可以描绘肝脏在宽频率范围内的流变行为。方法采用剪切波散射超声振动测量（SDUV）的超声弹性成像方法，在100～400Hz的频率范围内测量肝脏中剪切波的相速度，并用流变仪在1～30Hz的频率内获得复剪切模量。Maxwell、Voigt和Zener三个流变模型与两种不同方法和两种方法组合获得的测量数据相拟合。结果SDUV测得的弹性与流变仪测得的结果基本一致。然而，通过SDUV测量的粘度与流变仪测量的粘度显著不同。结果表明，色散数据的高频分量在确定色散模式或粘性值方面比低频分量起着更重要的作用。研究发现，在描述肝脏流变行为方面，Maxwell模型不如Voigt和Zener模型合适。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biorheology 医学-工程：生物医学

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials. The scope of papers solicited by Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.