A case of 10-year retrograde amnesia, cognitive dysfunction, and hippocampal atrophy after limbic encephalitis associated with rickettsiosis

Psychiatry research case reports Pub Date : 2023-07-21 DOI:10.1016/j.psycr.2023.100146

Naomichi Okamoto , Atsuko Ikenouchi , Shoichi Shimizu , Satoru Ide , Enkhmurun Chibaatar , Reiji Yoshimura

{"title":"A case of 10-year retrograde amnesia, cognitive dysfunction, and hippocampal atrophy after limbic encephalitis associated with rickettsiosis","authors":"Naomichi Okamoto , Atsuko Ikenouchi , Shoichi Shimizu , Satoru Ide , Enkhmurun Chibaatar , Reiji Yoshimura","doi":"10.1016/j.psycr.2023.100146","DOIUrl":null,"url":null,"abstract":"<div><p>Organisms in the genus <em>Rickettsia</em> are obligately intracellular gram-negative bacilli that are transmitted to humans via hematophagous arthropod vectors, and rickettsiosis is known to cause limbic encephalitis (LE). Here, we present a case of 10-year retrograde amnesia, cognitive dysfunction, and hippocampal atrophy of the brain following LE caused by rickettsiosis. A 76-year-old woman presented to the Medical Center for Dementia for reexamination and rethinking of the diagnosis of amnesia and cognitive dysfunction. She was diagnosed with rickettsiosis by clinical view and treated with antibiotics three years ago. Head imaging showed a high signal in bilateral amygdala and hippocampus. The current test showed enlarged ventricles, suggesting brain atrophy. This case report suggests that LE caused by rickettsiosis may cause persisting memory impairment, cognitive dysfunction, and brain atrophy. Clinicians must determine appropriate treatment considering the long-term sequelae of rickettsiosis.</p></div>","PeriodicalId":74594,"journal":{"name":"Psychiatry research case reports","volume":"2 2","pages":"Article 100146"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatry research case reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2773021223000445","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Organisms in the genus Rickettsia are obligately intracellular gram-negative bacilli that are transmitted to humans via hematophagous arthropod vectors, and rickettsiosis is known to cause limbic encephalitis (LE). Here, we present a case of 10-year retrograde amnesia, cognitive dysfunction, and hippocampal atrophy of the brain following LE caused by rickettsiosis. A 76-year-old woman presented to the Medical Center for Dementia for reexamination and rethinking of the diagnosis of amnesia and cognitive dysfunction. She was diagnosed with rickettsiosis by clinical view and treated with antibiotics three years ago. Head imaging showed a high signal in bilateral amygdala and hippocampus. The current test showed enlarged ventricles, suggesting brain atrophy. This case report suggests that LE caused by rickettsiosis may cause persisting memory impairment, cognitive dysfunction, and brain atrophy. Clinicians must determine appropriate treatment considering the long-term sequelae of rickettsiosis.

查看原文本刊更多论文

立克次体病相关边缘脑炎后10年逆行性遗忘、认知功能障碍和海马萎缩1例

立克次体属的有机体专为细胞内革兰氏阴性杆菌，通过嗜血节肢动物媒介传播给人类，立克次体病已知可引起边缘脑炎(LE)。在这里，我们报告一例立克次体病引起的LE后10年逆行性遗忘，认知功能障碍和大脑海马萎缩。一位76岁的女性在痴呆症医学中心进行复查，并重新思考失忆和认知功能障碍的诊断。三年前经临床诊断为立克次体病，并给予抗生素治疗。头部成像显示双侧杏仁核和海马高信号。目前的检查显示脑室增大，表明脑萎缩。本病例报告提示由立克次体病引起的LE可引起持续性记忆障碍、认知功能障碍和脑萎缩。临床医生必须考虑到立克次体病的长期后遗症，确定适当的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Psychiatry research case reports Medicine and Dentistry (General)

自引率

0.00%

发文量