A coupled SPH-EBG numerical model for deformations of MCF7 cancer cell in a microchannel flow

IF 1.7 4区工程技术 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

International Journal for Numerical Methods in Fluids Pub Date : 2023-07-16 DOI:10.1002/fld.5226

Jia Min Lee, Wai Lee Chan

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Abstract

Properties of a cell can determine its deformations, which can aggravate cancer metastasis. In laboratory, microfluidic technology has been adopted to study cell deformations. However, quantifying the effects of cell deformations has remained difficult. To this end, this paper presents a two-dimensional particle-based model that can capture flow-induced cell deformations in a microchannel. The numerical model is validated with an experimental dataset for MCF7 cell. The simulations show that cell deformations are dominantly attributed to flow acceleration. Stress analyses, conducted by inputting the simulated cell deformations as boundary conditions, show that the maximum normal stresses correspond well to high deformations. Shear stress is in general proportional to the cell's distance from a wall. The simulations also suggest a deformed cell shape that apparently may reduce the average normal stresses. This study highlights the potential of the numerical model to relate the measurable cell deformations to the more elusive cell properties.

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微通道流动中MCF7癌细胞变形的耦合SPH - EBG数值模型

细胞的特性决定了它的变形，而变形会加剧癌细胞的转移。在实验室中，微流体技术已被用于研究细胞变形。然而，量化细胞变形的影响仍然很困难。为此，本文提出了一个二维基于粒子的模型，可以捕捉微通道中流动诱导的细胞变形。利用MCF7单元的实验数据对数值模型进行了验证。仿真结果表明，细胞变形主要归因于流动加速度。将模拟的胞体变形作为边界条件进行应力分析，结果表明，最大法向应力与大变形相对应。剪切应力一般与细胞与壁的距离成正比。模拟还表明，变形的细胞形状显然可以降低平均正常应力。这项研究强调了数值模型的潜力，将可测量的细胞变形与更难以捉摸的细胞特性联系起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal for Numerical Methods in Fluids 物理-计算机：跨学科应用

CiteScore

3.70

自引率

5.60%

发文量

111

审稿时长

8 months

期刊介绍： The International Journal for Numerical Methods in Fluids publishes refereed papers describing significant developments in computational methods that are applicable to scientific and engineering problems in fluid mechanics, fluid dynamics, micro and bio fluidics, and fluid-structure interaction. Numerical methods for solving ancillary equations, such as transport and advection and diffusion, are also relevant. The Editors encourage contributions in the areas of multi-physics, multi-disciplinary and multi-scale problems involving fluid subsystems, verification and validation, uncertainty quantification, and model reduction. Numerical examples that illustrate the described methods or their accuracy are in general expected. Discussions of papers already in print are also considered. However, papers dealing strictly with applications of existing methods or dealing with areas of research that are not deemed to be cutting edge by the Editors will not be considered for review. The journal publishes full-length papers, which should normally be less than 25 journal pages in length. Two-part papers are discouraged unless considered necessary by the Editors.