Recent advances in hyaluronic acid-based hydrogels for 3D bioprinting in tissue engineering applications

Q1 Engineering
Yan-Wen Ding , Xu-Wei Zhang , Chen-Hui Mi , Xin-Ya Qi , Jing Zhou , Dai-Xu Wei
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引用次数: 43

Abstract

3D bioprinting technology can rapidly process cell-loaded biomaterials to prepare personalized scaffolds for repairing defective tissues, tissue regeneration, and even printing tissues or organs. 3D bioprinting relies on bioinks with appropriate rheology and cytocompatibility, and hydrogels are among the most promising bioink materials for 3D bioprinting. Among many hydrogel precursor materials, hyaluronic acid (HA) stands out due to its excellent physicochemical and biological properties, such as biocompatibility, hydrophilicity, non-immunogenicity, and complete biodegradability, and has become the most attractive hydrogel precursor for bioinks. In this review, we discuss the strategies adopted for the application of HA-based hydrogels as bioinks, including printability, improving their mechanical properties, and printing with loaded cells. Finally, we summarize the application of 3D bioprinted HA-based hydrogels in various tissue engineering applications in recent years, with the aim to provide fresh inspiration for further development of HA-based hydrogels for 3D bioprinting.

透明质酸基水凝胶在组织工程3D生物打印中的应用进展
生物3D打印技术可以快速加工装载细胞的生物材料,制备个性化支架,用于修复缺陷组织、组织再生,甚至打印组织或器官。3D生物打印依赖于具有适当流变学和细胞相容性的生物墨水,而水凝胶是3D生物打印最有前途的生物墨水材料之一。在众多水凝胶前驱体材料中,透明质酸(HA)以其优异的生物相容性、亲水性、非免疫原性、完全生物降解性等物理化学和生物学特性脱颖而出,成为最具吸引力的生物墨水水凝胶前驱体材料。在这篇综述中,我们讨论了ha基水凝胶作为生物墨水的应用策略,包括可印刷性,提高其机械性能,以及负载细胞的印刷。最后,总结了近年来生物3D打印ha基水凝胶在各种组织工程应用中的应用,旨在为生物3D打印ha基水凝胶的进一步发展提供新的灵感。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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