Expression and clinical significance of Th17 cells and cytokine IL-17 in peripheral blood of patients with Parkinson’s disease

国际医药卫生导报 Pub Date : 2019-12-25 DOI:10.3760/CMA.J.ISSN.1007-1245.2019.24.029

Chen Caixia, Zhang Xiaoyuan

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Abstract

Objective To analyze the expression of Th17 cells and cytokine IL-17 in peripheral blood of patients with Parkinson's disease (PD) and its relationship with antioxidant enzymes and peripheral nerve injury, so as to provide reference for clinical treatment of PD. Methods 60 patients with PD were enrolled in the case group in our hospital from September 2016 to September 2018. At the same time, 50 healthy adults were selected as the control group. The differences of Th17 cells, IL-17, SOD, GSH-Px, catalase (CAT) in peripheral blood, MCV, LP and Amp between the two groups were compared. The relationships between the percentage of Th17 cells, the concentration of IL-17 in peripheral blood and SOD, GSH-Px, CAT, MCV, LP, Amp were also analyzed. Results The percentage of Th17 cells and the concentration of IL-17 in peripheral blood in the case group were significantly higher than those in the control group (P<0.05), the concentrations of SOD, GSH-Px, and CAT in the case group were significantly lower than those in the control group (P<0.05), MCV and AMP of common peroneal nerve in the case group were significantly lower than those in the control group (P<0.05), LP was longer than that in the control group (P<0.05). The percentage of Th17 cells and the concentration of IL-17 were negatively correlated with SOD, GSH-Px, CAT, MCV, and AMP, respectively (P<0.05), positively correlated with LP (P<0.05). Conclusion The expression of Th17 cells and IL-17 in peripheral blood of patients with PD are increased, and the activity of antioxidant enzymes is decreased, which may be an important factor leading to peripheral nerve injury. Therefore, it is beneficial to alleviate peripheral nerve injury in patients with PD to reduce the expression of Th17 cells and IL-17 by intervention, and enhance the activity of antioxidant enzymes, which has certain guiding significance for the clinical treatment of PD. Key words: Parkinson's disease; Th17 cells; Interleukin-17 (IL-17); Neurons

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Th17细胞和细胞因子IL-17在帕金森病患者外周血中的表达及临床意义

目的分析帕金森病(PD)患者外周血中Th17细胞及细胞因子IL-17的表达及其与抗氧化酶及周围神经损伤的关系，为PD的临床治疗提供参考。方法选取2016年9月~ 2018年9月我院PD患者60例作为病例组。同时选取50名健康成人作为对照组。比较两组大鼠外周血Th17细胞、IL-17、SOD、GSH-Px、过氧化氢酶(CAT)、MCV、LP、Amp的差异。分析Th17细胞百分比、外周血IL-17浓度与SOD、GSH-Px、CAT、MCV、LP、Amp的关系。结果的百分比Th17细胞和外周血中的IL-17浓度在组明显高于对照组(P < 0.05), SOD的含量,氧化酶,和猫在组明显低于对照组(P < 0.05),主音箱腓总神经在组明显低于对照组(P < 0.05), LP是长于对照组(P < 0.05)。Th17细胞百分比和IL-17浓度分别与SOD、GSH-Px、CAT、MCV、AMP呈负相关(P<0.05)，与LP呈正相关(P<0.05)。结论PD患者外周血中Th17细胞和IL-17表达升高，抗氧化酶活性降低，可能是导致周围神经损伤的重要因素。因此，通过干预降低Th17细胞和IL-17的表达，增强抗氧化酶的活性，有利于减轻PD患者周围神经损伤，对PD的临床治疗具有一定的指导意义。关键词:帕金森病;Th17细胞;Interleukin-17 (IL-17);神经元

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国际医药卫生导报

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