Plasminogen Activator Inhibitor-1 4G/5G Promoter Polymorphism in Indian Patients with Deep Vein Thrombosis.

IF 0.7 4区医学 Q4 HEMATOLOGY

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-04-01 Epub Date: 2023-05-08 DOI:10.1007/s12288-023-01660-3

Saniya Sharma, Manu Jamwal, Varun Uppal, Hari Kishan Senee, Manav Jindal, Jasmina Ahluwalia, Reena Das, Neelam Varma, Pankaj Malhotra, Narender Kumar

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引用次数: 0

Abstract

A single guanosine deletion/insertion (4G/5G) polymorphism in the promoter region of plasminogen activator inhibitor-1 (PAI-1) gene encoding PAI-1 protein has been investigated in deep vein thrombosis (DVT) patients. The association between PAI-1 4G/5G polymorphism and increased risk of DVT has been reported in some studies, while others have reported a lack of association. The present study aimed to investigate if the PAI-1 4G/5G polymorphism is associated with an increased risk of DVT in the Indian population and to assess its association with thrombophilic risk factors. Fifty-two adult patients with a history of chronic or recurrent DVT and 52 healthy adult controls were genotyped for PAI-1 4G/5G polymorphism. Plasma levels of PAI-1 and other thrombophilic risk factors were also measured. PAI-1 4G/5G polymorphism was not significantly associated with an increased risk of DVT. Protein C deficiency was significantly associated with the 4G/4G genotype. Patients with the 4G/4G genotype had significantly reduced PAI-1 levels as compared to the controls. PAI-1 4G/5G polymorphism did not significantly contribute to an increased risk of DVT in the Indian population. However, in the presence of thrombophilic risk factor abnormalities, the risk of DVT is increased in individuals with the 4G/4G genotype in the Indian cohort.

Supplementary information: The online version contains supplementary material available at 10.1007/s12288-023-01660-3.

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印度深静脉血栓形成患者纤溶酶原激活物抑制剂1 4G/5G启动子多态性研究

研究人员对深静脉血栓（DVT）患者体内编码 PAI-1 蛋白的纤溶酶原激活物抑制剂-1（PAI-1）基因启动子区域的单鸟苷缺失/插入（4G/5G）多态性进行了调查。一些研究报告了 PAI-1 4G/5G 多态性与深静脉血栓风险增加之间的关联，而另一些研究则报告说两者之间没有关联。本研究旨在调查 PAI-1 4G/5G 多态性是否与印度人群深静脉血栓风险增加有关，并评估其与嗜血栓风险因素的关联。研究人员对 52 名有慢性或复发性深静脉血栓病史的成年患者和 52 名健康成年对照者进行了 PAI-1 4G/5G 多态性基因分型。同时还测定了血浆中 PAI-1 和其他嗜血栓风险因素的水平。PAI-1 4G/5G 多态性与深静脉血栓风险的增加无明显关联。蛋白 C 缺乏症与 4G/4G 基因型明显相关。与对照组相比，4G/4G 基因型患者的 PAI-1 水平明显降低。在印度人群中，PAI-1 4G/5G 多态性并没有明显导致深静脉血栓风险的增加。然而，如果存在嗜血栓风险因素异常，印度队列中 4G/4G 基因型的个体发生深静脉血栓的风险会增加：在线版本包含补充材料，可在 10.1007/s12288-023-01660-3上查阅。

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来源期刊

Indian Journal of Hematology and Blood Transfusion HEMATOLOGY-

CiteScore

1.70

自引率

0.00%

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审稿时长

>12 weeks

期刊介绍： Indian Journal of Hematology and Blood Transfusion is a medium for propagating and exchanging ideas within the medical community. It publishes peer-reviewed articles on a variety of aspects of clinical hematology, laboratory hematology and hemato-oncology. The journal exists to encourage scientific investigation in the study of blood in health and in disease; to promote and foster the exchange and diffusion of knowledge relating to blood and blood-forming tissues; and to provide a forum for discussion of hematological subjects on a national scale. The Journal is the official publication of The Indian Society of Hematology & Blood Transfusion.

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