{"title":"Critical review of bio/nano sensors for arsenic detection","authors":"Chenghua Zong , Xiaoting Jin , Juewen Liu","doi":"10.1016/j.teac.2021.e00143","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span>Detection of arsenic is a long-standing challenge in environmental analytical chemistry. In recent years, using biomolecules and </span>nanomaterials for sensing arsenic has been growingly reported. In this article, this field is critically reviewed based on some recent fundamental understandings including interactions between arsenic and gold, thiol, and </span>DNA aptamers. First, taking advantage of the adsorption of As(III) on noble metal surfaces such as </span>silver<span><span> and gold, sensors were developed based on surface enhanced Raman spectroscopy, electrochemistry<span> and colorimetry. In addition, by functionalizing </span></span>metal nanoparticles<span> with thiol containing molecules, As(III) induced aggregation of the particles based on As(III)/thiol interactions. As(V) interacts with metal oxides strongly and competitive sensors were developed by displacing pre-adsorbed DNA oligonucleotides. A DNA aptamer was selected for As(III) and many sensors were reported based on this aptamer, although careful binding measurements indicated that the sequence has no affinity towards As(III). Overall, bio/nano systems are promising for the detection of arsenic. Future work on fundamental studies, searching for more specific arsenic binding materials and aptamers, incorporation of sensors into portable devices, and more systematic test of sensors in real samples could be interesting and useful research topics.</span></span></p></div>","PeriodicalId":56032,"journal":{"name":"Trends in Environmental Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":11.1000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.teac.2021.e00143","citationCount":"20","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Environmental Analytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214158821000301","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 20
Abstract
Detection of arsenic is a long-standing challenge in environmental analytical chemistry. In recent years, using biomolecules and nanomaterials for sensing arsenic has been growingly reported. In this article, this field is critically reviewed based on some recent fundamental understandings including interactions between arsenic and gold, thiol, and DNA aptamers. First, taking advantage of the adsorption of As(III) on noble metal surfaces such as silver and gold, sensors were developed based on surface enhanced Raman spectroscopy, electrochemistry and colorimetry. In addition, by functionalizing metal nanoparticles with thiol containing molecules, As(III) induced aggregation of the particles based on As(III)/thiol interactions. As(V) interacts with metal oxides strongly and competitive sensors were developed by displacing pre-adsorbed DNA oligonucleotides. A DNA aptamer was selected for As(III) and many sensors were reported based on this aptamer, although careful binding measurements indicated that the sequence has no affinity towards As(III). Overall, bio/nano systems are promising for the detection of arsenic. Future work on fundamental studies, searching for more specific arsenic binding materials and aptamers, incorporation of sensors into portable devices, and more systematic test of sensors in real samples could be interesting and useful research topics.
期刊介绍:
Trends in Environmental Analytical Chemistry is an authoritative journal that focuses on the dynamic field of environmental analytical chemistry. It aims to deliver concise yet insightful overviews of the latest advancements in this field. By acquiring high-quality chemical data and effectively interpreting it, we can deepen our understanding of the environment. TrEAC is committed to keeping up with the fast-paced nature of environmental analytical chemistry by providing timely coverage of innovative analytical methods used in studying environmentally relevant substances and addressing related issues.