Wireless electromagnetic neural stimulation patch with anisotropic guidance

IF 12.3 1区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

npj Flexible Electronics Pub Date : 2023-07-31 DOI:10.1038/s41528-023-00270-3

Bjarke Nørrehvedde Jensen, Yuting Wang, Alice Le Friec, Sadegh Nabavi, Mingdong Dong, Dror Seliktar, Menglin Chen

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Abstract

The human body is limited in healing neurological damage caused by diseases or traumatic injuries. Bioelectricity is a quintessential characteristic of neural tissue and has a crucial role in physiological and neurological therapeutics development. Here, a wireless electromagnetic neural stimulation patch was created, combining stimulation through electromagnetic induction with physical guidance cues through structural anisotropy. The melt electrowritten biocompatible, bioresorbable polycaprolactone anisotropic structure with glancing angle deposition of 80 nm gold directly endowed incorporation of a wireless energy harvesting component in the patch, as an electromagnetic stimulation delivery system directly interfacing with neural cells. The biocompatibility and the capacity of the patch to deliver electromagnetic stimulation and promote neurite outgrowth was confirmed in vitro. Electromagnetically (60 mV, 40 kHz, 2 h/day, 5 days) stimulated PC12 cells showed 73.2% increased neurite outgrowth compared to PC12 cells grown without electromagnetic stimulation. The neural stimulation patch shows great potential for wireless electromagnetic stimulation for non-invasive neurological therapeutics advancement.

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各向异性导向的无线电磁神经刺激贴片

人体对疾病或外伤造成的神经损伤的愈合能力有限。生物电是神经组织的典型特征，在生理和神经治疗学的发展中起着至关重要的作用。在此，我们制作了一种无线电磁神经刺激贴片，将电磁感应刺激与结构各向异性的物理引导线索相结合。熔融电写的生物相容性、生物可吸收性聚己内酯各向异性结构与 80 纳米金的闪烁角沉积直接赋予了贴片中无线能量采集组件的功能，使其成为与神经细胞直接连接的电磁刺激传输系统。体外实验证实了这种贴片的生物相容性以及提供电磁刺激和促进神经元生长的能力。与未接受电磁刺激的 PC12 细胞相比，接受电磁刺激（60 mV、40 kHz、2 小时/天、5 天）的 PC12 细胞的神经元突起增加了 73.2%。神经刺激贴片显示了无线电磁刺激在非侵入性神经治疗方面的巨大潜力。

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来源期刊

npj Flexible Electronics Multiple-

CiteScore

17.10

自引率

4.80%

发文量

审稿时长

6 weeks

期刊介绍： npj Flexible Electronics is an online-only and open access journal, which publishes high-quality papers related to flexible electronic systems, including plastic electronics and emerging materials, new device design and fabrication technologies, and applications.