Point of care approaches to 3D bioprinting for wound healing applications

IF 5 Q1 ENGINEERING, BIOMEDICAL
Eileen R. Wallace, Z. Yue, M. Dottori, F. Wood, M. Fear, G. Wallace, S. Beirne
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引用次数: 3

Abstract

In the quest to improve both aesthetic and functional outcomes for patients, the clinical care of full-thickness cutaneous wounds has undergone significant development over the past decade. A shift from replacement to regeneration has prompted the development of skin substitute products, however, inaccurate replication of host tissue properties continues to stand in the way of realising the ultimate goal of scar-free healing. Advances in three-dimensional (3D) bioprinting and biomaterials used for tissue engineering have converged in recent years to present opportunities to progress this field. However, many of the proposed bioprinting strategies for wound healing involve lengthy in-vitro cell culture and construct maturation periods, employ complex deposition technologies, and lack credible point of care (POC) delivery protocols. In-situ bioprinting is an alternative strategy which can combat these challenges. In order to survive the journey to bedside, printing protocols must be curated, and biomaterials/cells selected which facilitate intraoperative delivery. In this review, the current status of in-situ 3D bioprinting systems for wound healing applications is discussed, highlighting the delivery methods employed, biomaterials/cellular components utilised and anticipated translational challenges. We believe that with the growth of collaborative networks between researchers, clinicians, commercial, ethical, and regulatory experts, in-situ 3D bioprinting has the potential to transform POC wound care treatment.
用于伤口愈合应用的3D生物打印的护理点方法
为了改善患者的美观和功能,全层皮肤伤口的临床护理在过去十年中取得了重大进展。从替代到再生的转变促使了皮肤替代产品的开发,然而,宿主组织特性的不准确复制仍然阻碍着实现无疤痕愈合的最终目标。近年来,三维(3D)生物打印和用于组织工程的生物材料的进展已经融合在一起,为该领域的发展提供了机会。然而,许多提出的用于伤口愈合的生物打印策略涉及漫长的体外细胞培养和构建体成熟期,使用复杂的沉积技术,并且缺乏可靠的护理点(POC)递送方案。原位生物打印是一种可以应对这些挑战的替代策略。为了在到达床边的旅程中幸存下来,必须策划打印方案,并选择有助于术中分娩的生物材料/细胞。在这篇综述中,讨论了用于伤口愈合应用的原位3D生物打印系统的现状,重点介绍了所采用的递送方法、所使用的生物材料/细胞成分以及预期的转化挑战。我们相信,随着研究人员、临床医生、商业、伦理和监管专家之间合作网络的发展,原位3D生物打印有可能改变POC伤口护理治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
9.40
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