Prescription Medication Use and Phantom Odor Perception Among US Adults

IF 1 4区医学 Q4 Neuroscience

Chemosensory Perception Pub Date : 2019-12-05 DOI:10.1007/s12078-019-09276-6

Kathleen E. Bainbridge, Danita Byrd-Clark

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引用次数: 1

Abstract

Prescription medication use may be associated with phantom odor perception. We evaluated associations between number of prescription medications and their therapeutic class and phantom odor perception among US adults.

Data were collected between 2011 and 2014 as part of the National Health and Nutrition Examination Survey (NHANES). A complex sampling design resulted in a nationally representative sample of 7417 adults aged 40 years and older. During an in-home interview, participants were asked whether they had experienced an unpleasant, bad, or burning odor when nothing is there. Prescription medication use was assessed using validation with prescription bottles, when possible.

Almost one quarter (23.3%) of adults uses ≥ 5 prescription medications. Use of five or more prescription medications is associated with 70% greater odds of phantom odor perception (OR 1.69 (1.09, 2.63)). Among adults 60 years and older, antidiabetic medications, antihyperlipidemic agents, and proton pump inhibitors are associated with 74–88% greater odds of report of phantom odor (OR = 1.74 (1.09, 2.77), OR = 1.85 (1.22. 2.80), and OR = 1.88 (1.15, 3.07)), respectively.

Phantom odor perception may be a side effect of antidiabetic or antihyperlipidemic agents. Among people taking proton pump inhibitors, phantom odors may also be a consequence of gastric gas reflux.

Common prescription medications may be providing an olfactory stimulus.

Abstract Image

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美国成年人的处方药使用和幻臭感知

处方药物的使用可能与幻闻感有关。我们评估了美国成年人中处方药数量及其治疗类别和幻臭感知之间的关系。数据收集于2011年至2014年，是国家健康和营养检查调查(NHANES)的一部分。复杂的抽样设计产生了7417名40岁及以上成年人的全国代表性样本。在一次家庭访谈中，参与者被问及他们是否在没有气味的情况下经历过令人不快的、难闻的或燃烧的气味。在可能的情况下，使用处方瓶对处方药使用进行评估。近四分之一(23.3%)的成年人使用≥5种处方药。使用五种或五种以上的处方药与70%以上的幻臭感知相关(or 1.69(1.09, 2.63))。在60岁及以上的成年人中，降糖药物、降血脂药物和质子泵抑制剂与幻臭报告的几率增加74-88%相关(OR = 1.74 (1.09, 2.77)， OR = 1.85(1.22)。OR = 1.88(1.15, 3.07))。幻臭感可能是抗糖尿病或抗高脂血症药物的副作用。在服用质子泵抑制剂的人群中，幻臭也可能是胃气反流的结果。常见的处方药可能会提供嗅觉刺激。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemosensory Perception 农林科学-神经科学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： Coverage in Chemosensory Perception includes animal work with implications for human phenomena and explores the following areas: Identification of chemicals producing sensory response; Identification of sensory response associated with chemicals; Human in vivo response to chemical stimuli; Human in vitro response to chemical stimuli; Neuroimaging of chemosensory function; Neurological processing of chemoreception; Chemoreception mechanisms; Psychophysics of chemoperception; Trigeminal function; Multisensory perception; Contextual effect on chemoperception; Behavioral response to chemical stimuli; Physiological factors affecting and contributing to chemoperception; Flavor and hedonics; Memory and chemoperception.