Synthesis of α-Sulfoximino Tetrazoles via Azido-Ugi Four-Component Reaction

Abstract

The sulfoximine based tetrazoles have been synthesized via Azido-Ugi four component reactions of sulfoximines, isocyanides, aldehydes, and TMS-azide in MeOH at 70 ℃ in the presence of InCl3. Replacement of sulfoximine with sulfonimidamide (SIA) have delivered corresponding SIA based tetrazole. Interestingly, SIA is also acting as a surrogate amine to accomplish corresponding aminotetrazole as by-product.