Immunostimulatory Effect of Moringa oleifera Extracts on Cyclophosphamide-induced Immunosuppressed Mice

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-06-08 DOI:10.1080/10496475.2021.1934620

Anh Thi Van Pham, Minh Hien Luong, Hang Thi Thu Dinh, Thanh Phuong Mai, Q. Trinh, L. H. Luong

引用次数: 1

Abstract

ABSTRACT In this study, the effect of Moringa oleifera extracts were investigated on an immunosuppressed model of cyclophosphamide-induced Swiss mice. M. oleifera seed and root extracts (2.0 g kg−1 body wt) were administered orally for 7 consecutive days; cyclophosphamide (CP) (200 mg kg−1 i.p.) was administered by IV on the 4th day. Results indicated that the extracts of the M. oleifera seeds and roots ameliorated the immunosuppressive effects of CP on delayed type hypersensitivity (DTH) response, leukocyte counts, relative organ weight, IgM concentration, serum TNF-α assay and micro-histological images. This study demonstrated in vivo the therapeutic effect of M. oleifera on the immune response in clinical application.

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辣木提取物对环磷酰胺诱导的免疫抑制小鼠的免疫刺激作用

摘要本研究采用环磷酰胺诱导的瑞士小鼠免疫抑制模型，研究辣木提取物的作用。连续7天口服M.oleifera种子和根提取物（2.0 g kg−1体重）；第4天静脉注射环磷酰胺（CP）（200 mg kg−1 i.p.）。结果表明，油籽和油根提取物改善了CP对迟发型超敏反应、白细胞计数、相对器官重量、IgM浓度、血清TNF-α测定和显微组织学图像的免疫抑制作用。本研究在体内证明了油在临床应用中对免疫反应的治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.