Medroxyprogesterone acetate improves propionic acid-induced autism rat model and magnetic resonance spectroscopic correlation

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2022-06-16 DOI:10.3329/bjp.v17i2.59412

M. Bozkurt, Muhammad Nasir Bhaya, I. H. Sever, B. Özkul, O. Erbaş

引用次数: 2

Abstract

The protective effect of medroxyprogesterone acetate on propionic acid-induced autism in rats was evaluated. For this purpose, 30 rats were divided into three groups. The significant difference in the levels of IL-17 (p<0.05), IL-2 (p<0.05), and TNF-α (p<0.05), lactate (p<0.05), and nerve growth factor (p<0.05) were found in the medroxyprogesterone-treated group by biochemical analysis. In histopathological examination, the medroxyprogesterone-treated group revealed significant improvement in neural body degeneration, neural count, and dysmorphological changes in both CA1 and CA3 regions. Immunohistochemical examination revealed improvement in glial activity with glial fibrillar acidic protein and morphological changes in Purkinje cells. Magnetic resonance spectroscopy showed an improvement in the level of lactate duplets in the medroxyprogesterone-treated group. To our knowledge, this is the first study, to evaluate the protective effect of medroxyprogesterone on propionic acid-induced autism in rats.

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醋酸甲孕酮改善丙酸致自闭症大鼠模型及磁共振波谱相关性

评价了醋酸甲羟孕酮对丙酸诱导的大鼠自闭症的保护作用。为此，将30只大鼠分为三组。生化分析发现，甲羟孕酮治疗组的IL-17（p<0.05）、IL-2（p<0.05）和TNF-α（p<0.05），乳酸（p<0.05）以及神经生长因子（p<0.05）水平存在显著差异。在组织病理学检查中，甲羟孕酮治疗组的CA1和CA3区域的神经体变性、神经计数和畸形改变均有显著改善。免疫组织化学检查显示浦肯野细胞中胶质纤维酸性蛋白的胶质活性改善和形态学变化。磁共振波谱显示，甲羟孕酮治疗组的乳酸双链体水平有所改善。据我们所知，这是第一项评估甲羟孕酮对丙酸诱导的大鼠自闭症的保护作用的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.