Peptides in COVID-19 Clinical Trials—A Snapshot

K. Hilpert
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引用次数: 1

Abstract

Since the beginning of the COVID-19 pandemic, there has been a strong drive and desire to find effective treatments for and protection against the disease. On the webpage ClinicalTrials.gov, a total of 6505 clinical trials currently (September 2021) investigating various aspects of COVID-19 are registered. Of these, 124 studies involving peptides were identified. These 124 were further evaluated, and 88 trials that used peptides only for routine diagnostics were excluded. The remaining 36 trials were classified into 5 different classes according to their function: immunomodulatory (5 trials), regain homeostasis (10 trials), diagnostics/biomarkers (8 trials), vaccination (9 trials), and antiviral activity (4 trials, all overlap with immunomodulatory activities). In the current review, these 36 trials are briefly described and tabularly summarised. According to the estimated finish date, 14 trials have not yet finished. All of the finished trials are yet to report their results. Seven trials were based in the USA, and Egypt, France, the UK, Turkey, and the Russian Federation conducted three trials each. This review aims to present a snapshot of the current situation of peptides in COVID-19 clinical trials and provides a template to follow up on trials of interest; it does not claim to be a complete overview.
COVID-19临床试验中的肽
自新冠肺炎大流行开始以来,人们一直强烈希望找到有效的治疗方法和保护措施。在ClinicalTrials.gov网页上,目前(2021年9月)共注册了6505项临床试验,调查新冠肺炎的各个方面。在这些研究中,鉴定了124项涉及肽的研究。对这124项进行了进一步评估,排除了88项仅使用肽进行常规诊断的试验。其余36项试验根据其功能分为5类:免疫调节(5项试验)、恢复稳态(10项试验),诊断/生物标志物(8项试验)和疫苗接种(9项试验)以及抗病毒活性(4项试验,均与免疫调节活性重叠)。在目前的综述中,对这36项试验进行了简要描述和表格总结。根据预计完成日期,14项试验尚未完成。所有已完成的试验尚未报告结果。七项试验在美国进行,埃及、法国、英国、土耳其和俄罗斯联邦各进行了三项试验。这篇综述旨在简要介绍新冠肺炎临床试验中肽的现状,并为后续感兴趣的试验提供模板;它并不声称是一个完整的概述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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