Synthesis, characterization, and antibacterial activity of a new poly azo compound containing N-arylsuccinimid and dibenzobarrelene moieties

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2023-01-01 DOI:10.1515/hc-2022-0157

Njoya Abdou Salamou, Tamokou Jean-de-Dieu, Sopbué Fondjo Emmanuel, Matsuete Takongmo Germaine, Bitchagno Mbahbou T. Gabin, Peter F. W. Simon, A. Tsopmo, Kuiate Jules-Roger

引用次数: 0

Abstract

Abstract The present work describes the synthesis, characterization, and evaluation of the antibacterial activity of a new poly azo compound resulting from the coupling of a previously reported N-arylsuccinimid precursor 5 with the diazonium ion of aniline. This azo compound was characterized using its physical, elemental, and 1D and 2D spectroscopic data. The novel azo compound 7 (minimum inhibitory concentration [MIC] = 16–32 μg/mL) showed higher antibacterial activity than its precursor 5 (MIC = 32–64 μg/mL), although it was low compared to the reference drug ciprofloxacin (MIC = 0.5–4 μg/mL). Graphical abstract

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含N-芳基琥珀酰亚胺和二苯并巴龙烯部分的新型聚偶氮化合物的合成、表征及其抗菌活性

摘要本工作描述了一种新的聚偶氮化合物的合成、表征和抗菌活性的评估，该化合物是由先前报道的N-芳基琥珀酰亚胺前体5与苯胺的重氮离子偶联得到的。使用其物理、元素以及1D和2D光谱数据对该偶氮化合物进行了表征。新型偶氮化合物7（最小抑制浓度[MIC]=16-32 μg/mL）显示出比其前体5更高的抗菌活性（MIC=32–64 μg/mL），尽管与参考药物环丙沙星相比（MIC=0.5-4 μg/mL）。图形摘要

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.