Unravelling the effects of ibuprofen-acetaminophen infused copper-bioglass towards the creation of root canal sealant

IF 3.9 3区医学 Q2 ENGINEERING, BIOMEDICAL

Biomedical materials Pub Date : 2022-03-08 DOI:10.1088/1748-605X/ac5b83

C. S, Riju Chandran, Ramya R, D. D., B. S

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引用次数: 3

Abstract

Impact towards the tuneable characteristics of bioactive glasses (BAGs) has been explored; as there is no root canal sealant till date with ideal characteristics competent enough to manoeuvre the perplexing root canal architecture. Combeite, calcite and traces of cuprorivaite crystalline phases were validated for material formation, in which Cu 2P (XPS) peak authenticating the presence of copper in bioglass network (Cu-BAG). Spherical and platelet-like morphologies were observed and the grain size of Cu-BAG (∼100 nm) was lesser as compared to BAG (∼1 µm). These particle distributions impacted the porosity, and dominant non-bridging oxygens in Cu-BAG influences ionic dissolution, which subsequently enhanced the mineralization. These bioactive materials were loaded with acetaminophen and ibuprofen, corresponding organic moieties was confirmed through Fourier transform infra-red. These drugs loaded bioactive materials exhibited tremendous anti-inflammatory and anti-microbial behaviour with better sealing ability. Drug loaded bioglass paste filled in biomechanically prepared root canal was estimated for sealing potential, mineralization, micro leakage, and fracture resistance properties. Hydroxyl apatite growth was noted on the sealants, flower like protuberance confirmed the sealing potential of the prepared material. Bioglass exhibited promising characteristics required in a root canal sealant. This investigation is a step further towards tailoring the properties of bioactive materials as promising candidates in root canal obturation and thereof.

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揭示布洛芬-对乙酰氨基酚注入铜生物玻璃对根管密封剂产生的影响

已经探索了对生物活性玻璃（BAG）的可调谐特性的影响；因为到目前为止，还没有具有理想特性的根管封闭剂能够操纵令人困惑的根管结构。对于材料的形成，验证了Combeite、方解石和痕量铜晶相，其中Cu2P（XPS）峰证实了生物玻璃网络（Cu-BAG）中存在铜。观察到球形和片状形态，与BAG（～1µm）相比，Cu BAG的晶粒尺寸（～100 nm）较小。这些颗粒分布影响了孔隙率，并且Cu BAG中的主要非桥接氧影响离子溶解，从而增强了矿化。这些生物活性材料负载了对乙酰氨基酚和布洛芬，通过傅立叶变换红外光谱确认了相应的有机部分。这些药物负载的生物活性材料表现出巨大的抗炎和抗微生物行为，具有更好的密封能力。在生物力学制备的根管中填充载药生物玻璃糊剂，评估其封闭潜力、矿化、微渗漏和抗断裂性能。在密封剂上观察到羟基磷灰石的生长，花状突起证实了所制备材料的密封潜力。生物玻璃显示出根管封闭剂所需的良好特性。这项研究是进一步调整生物活性材料的特性，使其成为根管充填及其应用的有前途的候选者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical materials 工程技术-材料科学：生物材料

CiteScore

6.70

自引率

7.50%

发文量

294

审稿时长

3 months

期刊介绍： The goal of the journal is to publish original research findings and critical reviews that contribute to our knowledge about the composition, properties, and performance of materials for all applications relevant to human healthcare. Typical areas of interest include (but are not limited to): -Synthesis/characterization of biomedical materials- Nature-inspired synthesis/biomineralization of biomedical materials- In vitro/in vivo performance of biomedical materials- Biofabrication technologies/applications: 3D bioprinting, bioink development, bioassembly & biopatterning- Microfluidic systems (including disease models): fabrication, testing & translational applications- Tissue engineering/regenerative medicine- Interaction of molecules/cells with materials- Effects of biomaterials on stem cell behaviour- Growth factors/genes/cells incorporated into biomedical materials- Biophysical cues/biocompatibility pathways in biomedical materials performance- Clinical applications of biomedical materials for cell therapies in disease (cancer etc)- Nanomedicine, nanotoxicology and nanopathology- Pharmacokinetic considerations in drug delivery systems- Risks of contrast media in imaging systems- Biosafety aspects of gene delivery agents- Preclinical and clinical performance of implantable biomedical materials- Translational and regulatory matters