A note on false Scott-test positives for uril-based macrocycles

IF 2.3 4区化学 Q2 Agricultural and Biological Sciences

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2023-09-04 DOI:10.1007/s10847-023-01201-5

Giovanni Batista de Santana Dias, Vitor Granero Lago, Grégoire Jean-François Demets

引用次数: 0

Abstract

This short note shows that the Scott test, which is widely used for the detection of cocaine by authorities, produces false-positives for the entire series of cucurbit[n]uril-type uril macrocycles and also for hemi-cucurbit[n]uril. For analogous macrocycles such as bambus[6]uril and biotin[6]uril this does not happen. This is a wake-up call to the scientific community and international authorities.

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关于基于uril的大循环的假斯科特测试阳性的说明

这篇简短的笔记表明，当局广泛用于检测可卡因的斯科特测试，对整个系列的葫芦[n]型uril大环和半葫芦[n]uril产生假阳性。对于类似的大循环，如竹bbbbl和生物素bbbbl，这种情况不会发生。这给科学界和国际当局敲响了警钟。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Inclusion Phenomena and Macrocyclic Chemistry 化学-化学综合

CiteScore

3.30

自引率

8.70%

发文量

审稿时长

3-8 weeks

期刊介绍： The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.