Light exposure during sleep impairs cardiometabolic function.

IF 11.3 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2022-03-22 Epub Date: 2022-03-14 DOI:10.1073/pnas.2113290119

Ivy C Mason, Daniela Grimaldi, Kathryn J Reid, Chloe D Warlick, Roneil G Malkani, Sabra M Abbott, Phyllis C Zee

引用次数: 0

Abstract

SignificanceAmbient nighttime light exposure is implicated as a risk factor for adverse health outcomes, including cardiometabolic disease. However, the effects of nighttime light exposure during sleep on cardiometabolic outcomes and the related mechanisms are unclear. This laboratory study shows that, in healthy adults, one night of moderate (100 lx) light exposure during sleep increases nighttime heart rate, decreases heart rate variability (higher sympathovagal balance), and increases next-morning insulin resistance when compared to sleep in a dimly lit (<3 lx) environment. Moreover, a positive relationship between higher sympathovagal balance and insulin levels suggests that sympathetic activation may play a role in the observed light-induced changes in insulin sensitivity.

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睡眠中的光照会损害心脏代谢功能

重要意义夜间环境光照暴露是包括心脏代谢疾病在内的不良健康后果的风险因素。然而，睡眠期间夜间光照对心脏代谢结果的影响及其相关机制尚不清楚。这项实验室研究表明，在健康成年人中，与在昏暗（<3 lx）环境中睡眠相比，睡眠中一晚适度（100 lx）的光照会增加夜间心率，降低心率变异性（交感迷走神经平衡更高），并增加第二天早上的胰岛素抵抗。此外，较高的交感迷走神经平衡与胰岛素水平之间的正相关关系表明，交感神经激活可能在观察到的光诱导的胰岛素敏感性变化中发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.