Potential of Carica papaya leaf extract as an future medicine for thrombocytopenia in dengue patients: from traditional to scientific drug discovery

IF 1.8 Q3 PHARMACOLOGY & PHARMACY

Advances in Traditional Medicine Pub Date : 2023-08-25 DOI:10.1007/s13596-023-00701-6

Dewangga Yudisthira, Fortuna Filly Firdausi, Citra Fadia Alyani, Fahrul Nurkolis, Harun Al Rasyid, Vincentius Mario Yusuf, Nurpudji Astuti Taslim

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引用次数: 0

Abstract

Dengue, widespread mosquito-borne disease, is endangering through thrombocytopenia which is a warning sign. Currently, therapy for thrombocytopenia is platelet transfusion. However, platelet transfusions are still controversial because of their side effects. Carica papaya Leaf Extract (CPLE) has become popular as a herbal medicine which is claimed to accelerate the increase in platelet levels in dengue fever patients. This article aims to review the potential of CPLE as an alternative therapy in order to accelerate clinical improvement in dengue patients, especially in patients with thrombocytopenia. Systematic review was conducted based on PRISMA guidelines using Google Scholar, Science Direct, Hindawi, PubMed, Cochrane, Taylor & Francis, Proquest, and Semantic Scholar databases in the last 10 years. The inclusion criteria follows the PICOS framework and the assessment of the quality of the literature is based on the Risk of Bias 2.0 Tools. A total of 10 valid and reliable articles demonstrated the effectiveness of CPLE increasing platelet levels in dengue fever patients. The duration of hospitalization and the need for platelet transfusions were also significantly lower in patients treated with CPLE than in controls. The use of CPLE has potential as adjuvant therapy in dengue fever patients with thrombocytopenia without causing major side effects.

Graphical abstract

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番木瓜叶提取物作为登革热患者血小板减少症未来药物的潜力：从传统药物到科学药物的发现

登革热是一种广泛传播的蚊媒疾病，通过血小板减少危及生命，这是一个警示信号。目前，血小板减少症的治疗方法是输注血小板。然而，由于血小板输注的副作用，目前仍存在争议。木瓜叶提取物（CPLE）作为一种草药已广为流行，据称可加速登革热患者血小板水平的升高。本文旨在回顾木瓜叶提取物作为替代疗法的潜力，以加速登革热患者，尤其是血小板减少症患者的临床改善。根据PRISMA指南，我们使用Google Scholar、Science Direct、Hindawi、PubMed、Cochrane、Taylor & Francis、Proquest和Semantic Scholar数据库对过去10年的研究进行了系统回顾。纳入标准遵循 PICOS 框架，文献质量评估基于偏倚风险 2.0 工具。共有 10 篇有效、可靠的文章证明了 CPLE 提高登革热患者血小板水平的有效性。接受 CPLE 治疗的患者的住院时间和血小板输注需求也明显低于对照组。CPLE有可能成为血小板减少登革热患者的辅助疗法，且不会产生重大副作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Traditional Medicine PHARMACOLOGY & PHARMACY-

CiteScore

4.30

自引率

0.00%

发文量

期刊介绍： Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.