Magnoflorine promotes Huh-7 cell apoptosis and autophagy by regulating PI3K/Akt/mTOR pathway

IF 4.6 3区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Quality Assurance and Safety of Crops & Foods Pub Date : 2022-01-20 DOI:10.15586/qas.v14i1.1013

Jifan Xu, Bo Du, Yunfeng Liu, Chonglin Tao

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Abstract

Hepatoma is a malignant tumor with high rates of heterogeneity, metastasis, and mortality. Currently, there is no effective treatment available for hepatoma. In order to treat advanced hepatoma in a better manner, new and more effective therapeutic targets still need to be developed. Magnoflorine (MGN) is a quaternary ammonium alkaloid with a variety of therapeutic properties. MGN inhibited the proliferation of lung cancer, breast cancer, glioma, and rhabdomyosarcoma cells, induced apoptosis, and blocked cell cycle. However, its possible effects on the progression of hepatoma are still indefinite. In this study, the effects of MGN on the progression of hepatoma in vitro and the underlying mechanisms were determined. MGN suppressed the proliferation, induced the autophagy, and stimulated the apoptosis of human hepatoma Huh-7 cells. Mechanically, MGN could regulate PI3K/AKT/mTOR pathway, which therefore affects the progression of hepatoma in vitro. Taken together, MGN affected Huh-7 cell proliferation, autophagy, and apoptosis, and might act as a promising therapeutic drug for treating hepatoma.

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magnnoflorine通过调节PI3K/Akt/mTOR通路促进Huh-7细胞凋亡和自噬

肝癌是一种异质性高、转移率高、死亡率高的恶性肿瘤。目前，尚无有效的肝癌治疗方法。为了更好地治疗晚期肝癌，还需要开发新的更有效的治疗靶点。magnnoflorine (MGN)是一种具有多种治疗特性的季铵盐生物碱。MGN抑制肺癌、乳腺癌、胶质瘤和横纹肌肉瘤细胞的增殖，诱导细胞凋亡，阻断细胞周期。然而，其对肝癌进展的可能影响仍不确定。在这项研究中，我们确定了MGN对体外肝癌进展的影响及其潜在机制。MGN抑制人肝癌Huh-7细胞增殖，诱导细胞自噬，促进细胞凋亡。在机械上，MGN可以调节PI3K/AKT/mTOR通路，从而影响肝癌的体外进展。综上所述，MGN影响Huh-7细胞的增殖、自噬和凋亡，可能是一种有前景的治疗肝癌的药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Quality Assurance and Safety of Crops & Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

4.60

自引率

7.50%

发文量

审稿时长

1 months

期刊介绍： ''Quality Assurance and Safety of Crops & Foods'' is an international peer-reviewed journal publishing research and review papers associated with the quality and safety of food and food sources including cereals, grains, oilseeds, fruits, root crops and animal sources. It targets both primary materials and their conversion to human foods. There is a strong focus on the development and application of new analytical tools and their potential for quality assessment, assurance, control and safety. The scope includes issues of risk assessment, traceability, authenticity, food security and socio-economic impacts. Manuscripts presenting novel data and information that are likely to significantly contribute to scientific knowledge in areas of food quality and safety will be considered. ''Quality Assurance and Safety of Crops & Foods'' provides a forum for all those working in the specialist field of food quality and safety to report on the progress and outcomes of their research.