Recent Progress in Fragmentation of Katritzky Salts Enabling Formation of C–C, C–B, and C–S Bonds

IF 8.6 2区化学 Q1 Chemistry

Topics in Current Chemistry Pub Date : 2022-05-19 DOI:10.1007/s41061-022-00381-x

Yuan Gao, Songwei Jiang, Nian-Dong Mao, Huan Xiang, Ji-Long Duan, Xiang-Yang Ye, Li-Wei Wang, Yang Ye, Tian Xie

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引用次数: 8

Abstract

Since their discovery in 1970s, Katritzky salts have emerged as one of the most important classes of building blocks for use in organic synthesis and drug discovery. These bulky pyridinium salts derived from alkylamine can readily generate alkyl radical and undergo a variety of organic transformation reactions such as alkylation, arylation, alkenylation, alkynylation, carbonylation, sulfonylation, and borylation. Through these transformations, complexed molecules bearing new C–C, C–B, or C–S bonds can be constructed in easy ways and in simple steps. This review aims to summarize recent advances in these versatile building blocks in well-classified categories. Representative examples and their reaction mechanisms are discussed. The hope is to provide the scientific community with convenient access to collective information and accelerate further research.

Graphical Abstract

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Katritzky盐碎片化使C–C、C–B和C–S键形成的最新进展

自20世纪70年代被发现以来，Katritzky盐已经成为有机合成和药物发现中最重要的构建模块之一。这些由烷基胺衍生的体积庞大的吡啶盐可以很容易地生成烷基自由基，并进行烷基化、芳基化、烯基化、烷基化、羰基化、磺化和硼化等多种有机转化反应。通过这些转化，具有新的C-C, C-B或C-S键的复杂分子可以以简单的方式和简单的步骤构建。这篇综述的目的是在分类良好的类别中总结这些多功能构建块的最新进展。讨论了典型实例及其反应机理。其目的是为科学界提供获取集体信息的便利途径，并加速进一步的研究。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.